As digitalisation creates both opportunities and challenges that transcend borders, international co-operation is a key dimension to make the most out of the digital transformation at local, national and international levels. This chapter describes how a renewed model of international co-operation can help LAC countries harness the digital transformation to foster their sustainable development. It first looks at how digital co-operation has helped LAC countries build their domestic capacities to overcome the interlinked challenges of the development traps, thus promoting a multi-dimensional approach to development and aligning national and international priorities. This chapter then explores how building a regional digital market can help the region tap into its digital potential, by harmonising strategies, articulating all levels of digital development and involving multiple stakeholders in a regional policy dialogue on digital issues. To do so, LAC countries can take advantage of useful international experiences, including the European Union’s digital strategy. Finally, LAC countries can also take advantage of being fully involved in multilateral initiatives to address issues arising from digitalisation, notably addressing the tax challenges arising from the digitalisation of the economy.