Regional and international co-operation is necessary to ensure the successful implementation of climate change mitigation and adaptation policies. Many countries in LAC are natural resource-intensive exporters with rich biodiversity, placing them as important actors in climate negotiations. However, they also face an export structure biased towards primary sectors, a condition that makes them vulnerable to new international environmental standards and regulations. This chapter argues that, to transition to a sustainable model of development, LAC governments need a strong convening power and to enhance a unified voice in multilateral environmental agendas. This will help to better illustrate the region’s particularities and improve alignment of national policies and internationally established environmental goals. In addition, the chapter looks at how governments will also have to face the green economy’s impact on trade. Policies will need to take into account the additional costs imposed on exports in the medium term, along with the effects of international environmental standards and regulations. Finally the chapter shows how regional co-ordination and further co-operation among LAC countries, and sub-regional grouping will be the way forward for advancing on renewable energies and green transition policies in the LAC region.