Most countries around the world are defining and implementing new strategies to reap the benefits and minimise the risks of the ongoing technological and geopolitical changes. Chile, in line with global trends, has updated its strategy to sustain productivity and enable a shift towards a more knowledge-based growth. Chilean firms, entrepreneurs and society are revealing a new openness to thinking long term and to identify a shared vision for the future. The current policy approach builds on previous experiences and, in a spirit of continuity, presents novel elements that contribute to make Chile advancing in its path towards prosperity. This chapter starts with a brief overview of global trends in strategies foreconomic transformation, with a focus on China, Germany, Sweden and Emilia Romagna (Italy). It assesses the current Chilean strategy focusing on its governance and its anticipation and adaptation capacity, propensity to foster learning and its interconnectedness and embeddedness potential. It concludes by identifying three game changers for Chile and its future development agenda.