This chapter identifies knowledge gaps in the study of systemic innovation in the VET sector for which further research might be beneficial. The benefits of such an effort could be (a) the improvement of the innovation capacity of national VET systems, particularly by identifying which drivers and barriers are operating in relation to systemic innovation; and (b) an increase in the quality of the processes and the outcomes of VET, by raising awareness of the necessary links between innovation efforts and system performance. The chapter also suggests that the main emphasis of research on systemic innovation in VET shall be put on the systemic factors that can foster innovation, on the processes taking place, and on the impact of systemic innovation on VET quality and outcomes. Additionally, the chapter discusses what could be the most suitable methodological strategies and requirements for systemic innovation and the corresponding policy implications for governments. In this latter respect, four seem to be the most urgent. The first is related to the need to develop national agendas on research on VET and more specifically on the processes of systemic innovation. The second is to incorporate systemic innovation in the national agenda. The last is that governments should benefit from the opportunities being offered by international comparative research in this domain, by way of benchmarking initiatives and developing policy lessons among peers.