Mark | Date Date | Title Title | |||
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No. 390 | 23 Nov 2023 |
OECD Omics Reporting Framework (OORF): Guidance on reporting elements for the regulatory use of omics data from laboratory-based toxicology studies
OECD Member Countries are interested in increasing the use of omics technologies in regulatory toxicology to advance chemical risk assessment. In this context, the OECD has developed this Guidance Document and accompanying Excel template for... |
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No. 386 | 21 Nov 2023 |
(Q)SAR Assessment Framework: Guidance for the regulatory assessment of (Quantitative) Structure Activity Relationship models and predictions
The aim of the OECD (Quantitative) Structure-Activity Relationship ((Q)SAR) Assessment Framework (QAF) is to provide a systematic and harmonised framework for the regulatory assessment of (Q)SAR models, predictions, and results based on multiple... |
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No. 381 | 24 Jul 2023 |
Detailed review paper (DRP) on the thyroid hormone system in fish and identification of potential thyroid hormone system related endpoints for inclusion in existing OECD fish Test Guidelines
International standardised test guidelines (TGs) with sensitive endpoints form the basis for hazard identification and characterisation and risk assessment used in the regulation of chemicals. The OECD has developed the Conceptual Framework for the... |
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No. 377 | 03 Nov 2023 |
Initial Recommendations on Evaluation of Data from the Developmental Neurotoxicity (DNT) In-Vitro Testing Battery
Developmental neurotoxic chemicals are a diverse set of substances that have the potential to interfere with the normal development of the nervous system, which, if perturbed without compensation, may lead to adverse effects on nervous system... |
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No. 370 | 22 Nov 2022 |
Occupational Biomonitoring Guidance Document
This occupational biomonitoring guidance document was elaborated in a joint activity including more than 40 institutes and organisations in collaboration with the OECD.The guidance document presents current approaches used to derive biomonitoring... |
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No. 361 | 08 Jul 2022 |
Best Practice Guide for Access and Protection of Proprietary Rights to Non-Clinical Health, Safety and Environmental Data and Information on Chemicals
This Best Practice Guide (BPG) was developed to support the implementation of the OECD Recommendation of the Council Concerning Access and Protection of Proprietary Rights to Non-Clinical Health, Safety and Environmental Data and Information on... |
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No. 360 | 19 Sept 2022 |
Detailed Review Paper on In Vitro Test Addressing Immunotoxicity With a Focus on Immunosuppression
This Detailed Review Paper (DRP) aims to present and discuss the application and interpretation of in vitro immunotoxicity assays, mainly covering immunosuppression, and to define an in vitro tiered approach to testing and assessment. A... |
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No. 358 | 19 Sept 2022 |
Detailed Review Paper on the miniaturised versions of the bacterial reverse gene mutation test
The bacterial reverse gene mutation test described in OECD Test Guideline 471 is the most widely used in vitro test for the detection of mutagenicity. The standard format utilises plate incorporation and/or preincubation method; a test mixture... |
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No. 356 | 24 Jul 2023 |
Performance Standards for the Assessment of Proposed Similar or Modified in Vitro Phototoxicity: Reconstructed Human Epidermis (RhE) Test Methods for Testing of Topically Applied Substances, as described in Test Guideline 498
This document contains Performance Standards which allow, in accordance with the principles of Guidance Document No. 34, determining the validation status (reliability and relevance) of similar and modified skin irritation test methods that are... |
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No. 351 | 17 Jun 2022 |
Establishing Occupational Exposure Limits
Occupational exposure limits (OELs) are derived internationally by many government agencies and professional organisations. The absence of a globally harmonised approach contributes towards differences in derivation approaches and resulting OEL... |
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No. 344 | 08 Dec 2021 |
Guidance Document for the scientific review of Adverse Outcome Pathways
The Adverse Outcome Pathway (AOP) framework has been developed to facilitate the collection of mechanistic information derived from toxicological science in a structured manner, to assist in establishing causal relationships between molecular and... |
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No. 343 | 21 Sept 2021 |
Detailed review paper on the Retinoid System
The aim of this document is to provide a more detailed overview of the understanding of the role of retinoid signalling in several organ systems for which more information may be known, as well as evaluate potential gaps in knowledge, and identify... |
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No. 342 | 28 Jul 2021 |
Guidance Document on testing Nanomaterials using OECD TG No. 312 “Leaching in soil columns"
This document provides specific guidance for test preparation, implementation, performance, analysis and reporting using the OECD TG No. 312 for testing the mobility and retention of NMs in different types of soils. The GD is likely also relevant for... |
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No. 332 | 16 Jul 2021 |
Guidance Document on Honey Bee (Apis mellifera L.) Homing Flight Test, using single oral exposure to sub-lethal doses of test chemical
This guidance document presents a standardised test evaluating the ability of honeybees (Apis mellifera) exposed to a single dose of test chemical to return to the hive; it is a semi-field test, where dietary exposure to the test chemical and bee... |
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No. 331 | 03 Feb 2021 |
Guidance document on the characterisation, validation and reporting of Physiologically Based Kinetic (PBK) models for regulatory purposes
The fields of toxicology and chemical risk assessment evaluate the safety of chemicals for humans the environment. Increasingly, modern methods seek to reduce the use of animals in chemical safety testing and predictive toxicology. In this context,... |
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No. 329 | 02 Oct 2020 |
Overview of Concepts and Available Guidance related to Integrated Approaches to Testing and Assessment (IATA)
The aim of this report is to give an overview of existing guidance on Integrated Approaches to Testing and Assessment (IATA) and their component parts. While the number of documents, from different sources, directly or indirectly related to guidance... |
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No. 318 | 20 Jul 2020 |
Guidance Document for the Testing of Dissolution and Dispersion Stability of Nanomaterials, and the Use of the Data for Further Environmental Testing and Assessment
This document provides guidance for the methods to address dissolution rate and dispersion stability for nanomaterials with focus on environmental aqueous media. The definition of nanomaterials as having one dimension between 1 and 100 nm is... |
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No. 317 | 31 Aug 2021 |
Guidance Document on Aquatic and Sediment Toxicological Testing of Nanomaterials
This document provides guidance for aquatic (including sediment) ecotoxicity testing of Manufactured Nanomaterials (MNs) to determine their hazard. The definition of MNs as having one dimension between 1 and 100 nm is generally adopted. However, the... |
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No. 314 | 19 Dec 2019 |
International Best Practices for Identification of Priorities within Chemicals Management Systems
This document captures and examines schemes used internationally for prioritising chemicals for risk assessment and/or risk management, and identifies commonalities, differences, lessons learned and areas for improvement. Based on this analysis it... |
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No. 313 | 09 Mar 2021 |
Performance Standards for the assessment of proposed similar or modified Vitrigel-Eye Irritancy method for Test Guideline 494
The purpose of Performance Standards (PS) is to provide a basis by which proposed similar or modified test methods, both proprietary (i.e., copyrighted, trademarked, or registered) and non-proprietary, can be deemed to be structurally and... |
OECD Series on Testing and Assessment
This Series includes publications related to testing and assessment of chemicals; some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance documents, detailed review papers).
English
- ISSN: 20777876 (online)
- https://doi.org/10.1787/20777876
1 - 20 of 144 results
OECD Omics Reporting Framework (OORF): Guidance on reporting elements for the regulatory use of omics data from laboratory-based toxicology studies
OECD
23 Nov 2023
OECD Member Countries are interested in increasing the use of omics technologies in regulatory toxicology to advance chemical risk assessment. In this context, the OECD has developed this Guidance Document and accompanying Excel template for...
(Q)SAR Assessment Framework: Guidance for the regulatory assessment of (Quantitative) Structure Activity Relationship models and predictions
OECD
21 Nov 2023
The aim of the OECD (Quantitative) Structure-Activity Relationship ((Q)SAR) Assessment Framework (QAF) is to provide a systematic and harmonised framework for the regulatory assessment of (Q)SAR models, predictions, and results based on multiple...
International standardised test guidelines (TGs) with sensitive endpoints form the basis for hazard identification and characterisation and risk assessment used in the regulation of chemicals. The OECD has developed the Conceptual Framework for the...
Initial Recommendations on Evaluation of Data from the Developmental Neurotoxicity (DNT) In-Vitro Testing Battery
OECD
03 Nov 2023
Developmental neurotoxic chemicals are a diverse set of substances that have the potential to interfere with the normal development of the nervous system, which, if perturbed without compensation, may lead to adverse effects on nervous system...
Occupational Biomonitoring Guidance Document
OECD
22 Nov 2022
This occupational biomonitoring guidance document was elaborated in a joint activity including more than 40 institutes and organisations in collaboration with the OECD.The guidance document presents current approaches used to derive biomonitoring...
Best Practice Guide for Access and Protection of Proprietary Rights to Non-Clinical Health, Safety and Environmental Data and Information on Chemicals
OECD
08 Jul 2022
This Best Practice Guide (BPG) was developed to support the implementation of the OECD Recommendation of the Council Concerning Access and Protection of Proprietary Rights to Non-Clinical Health, Safety and Environmental Data and Information on...
Detailed Review Paper on In Vitro Test Addressing Immunotoxicity With a Focus on Immunosuppression
OECD
19 Sept 2022
This Detailed Review Paper (DRP) aims to present and discuss the application and interpretation of in vitro immunotoxicity assays, mainly covering immunosuppression, and to define an in vitro tiered approach to testing and assessment. A...
Detailed Review Paper on the miniaturised versions of the bacterial reverse gene mutation test
OECD
19 Sept 2022
The bacterial reverse gene mutation test described in OECD Test Guideline 471 is the most widely used in vitro test for the detection of mutagenicity. The standard format utilises plate incorporation and/or preincubation method; a test mixture...
This document contains Performance Standards which allow, in accordance with the principles of Guidance Document No. 34, determining the validation status (reliability and relevance) of similar and modified skin irritation test methods that are...
Establishing Occupational Exposure Limits
OECD
17 Jun 2022
Occupational exposure limits (OELs) are derived internationally by many government agencies and professional organisations. The absence of a globally harmonised approach contributes towards differences in derivation approaches and resulting OEL...
The Adverse Outcome Pathway (AOP) framework has been developed to facilitate the collection of mechanistic information derived from toxicological science in a structured manner, to assist in establishing causal relationships between molecular and...
Detailed review paper on the Retinoid System
OECD
21 Sept 2021
The aim of this document is to provide a more detailed overview of the understanding of the role of retinoid signalling in several organ systems for which more information may be known, as well as evaluate potential gaps in knowledge, and identify...
Guidance Document on testing Nanomaterials using OECD TG No. 312 “Leaching in soil columns"
OECD
28 Jul 2021
This document provides specific guidance for test preparation, implementation, performance, analysis and reporting using the OECD TG No. 312 for testing the mobility and retention of NMs in different types of soils. The GD is likely also relevant for...
Guidance Document on Honey Bee (Apis mellifera L.) Homing Flight Test, using single oral exposure to sub-lethal doses of test chemical
OECD
16 Jul 2021
This guidance document presents a standardised test evaluating the ability of honeybees (Apis mellifera) exposed to a single dose of test chemical to return to the hive; it is a semi-field test, where dietary exposure to the test chemical and bee...
Guidance document on the characterisation, validation and reporting of Physiologically Based Kinetic (PBK) models for regulatory purposes
OECD
03 Feb 2021
The fields of toxicology and chemical risk assessment evaluate the safety of chemicals for humans the environment. Increasingly, modern methods seek to reduce the use of animals in chemical safety testing and predictive toxicology. In this context,...
Overview of Concepts and Available Guidance related to Integrated Approaches to Testing and Assessment (IATA)
OECD
02 Oct 2020
The aim of this report is to give an overview of existing guidance on Integrated Approaches to Testing and Assessment (IATA) and their component parts. While the number of documents, from different sources, directly or indirectly related to guidance...
This document provides guidance for the methods to address dissolution rate and dispersion stability for nanomaterials with focus on environmental aqueous media. The definition of nanomaterials as having one dimension between 1 and 100 nm is...
This document provides guidance for aquatic (including sediment) ecotoxicity testing of Manufactured Nanomaterials (MNs) to determine their hazard. The definition of MNs as having one dimension between 1 and 100 nm is generally adopted. However, the...
International Best Practices for Identification of Priorities within Chemicals Management Systems
OECD
19 Dec 2019
This document captures and examines schemes used internationally for prioritising chemicals for risk assessment and/or risk management, and identifies commonalities, differences, lessons learned and areas for improvement. Based on this analysis it...
Performance Standards for the assessment of proposed similar or modified Vitrigel-Eye Irritancy method for Test Guideline 494
OECD
09 Mar 2021
The purpose of Performance Standards (PS) is to provide a basis by which proposed similar or modified test methods, both proprietary (i.e., copyrighted, trademarked, or registered) and non-proprietary, can be deemed to be structurally and...