This report, crafted by the OECD LEED Programme, sheds light on the crucial role of local economic leadership in driving sustainable growth. Through the lens of Manchester's journey and lessons from global peers like Stockholm and Amsterdam, it underscores the essence of patient, collaborative, and evidence-based leadership. From fostering partnerships to catalyzing transformative initiatives, effective leadership transcends short-term actions to shape enduring progress. By prioritizing transparency, strategic planning, and institutional reforms, cities can unlock their full potential and navigate complex economic landscapes with confidence. This report serves as a beacon for aspiring leaders worldwide, offering invaluable insights for crafting resilient, inclusive, and prosperous local economies.