Responsible science communication is crucial for fostering public trust in science and promoting evidence-based policymaking. However, in an evolving landscape shaped by the digital transformation and complex crises like the COVID-19 pandemic, science communication faces new challenges including widespread mis- and disinformation. To address these challenges, science communicators should follow key principles for responsible science communication including transparency, inclusivity, integrity, accountability, freedom and autonomy, and timeliness. Policymakers in turn are encouraged to promote these principles, invest in science communication capacity, establish crisis communication structures, support scientists in public communication, and promote scientific and digital literacy.