Spallation reactions have recently attracted considerable attention due to their importance in technical applications and fundamental physics. For example, they can act as intense neutron sources for accelerator-driven radiologically clean nuclear systems (ADS) [1,2] for energy generation and nuclear waste transmutation. In this system, lead constitutes an ideal spallation target since its neutron yield is high and it is very transparent to neutrons of energies below 1 MeV. Isotopic production data from proton-induced reactions with energies up to 5 GeV are of great importance for understanding the reaction mechanisms of intermediate nuclear reactions. Recently, precise and numerous measurements of elements produced from proton-induced spallation reactions with energy ranges from 10 MeV to 5 GeV using several target materials were carried out [3-5] due to the interest in a spallation neutron source and ADS. More than 15 000 experimental data points have been obtained. R. Michel [3-5], et al., systematically investigated the data in order to provide a database for model calculations while Yu. E. Titarenko [6] measured the yields of residual product for proton energies from 100 to 2 600 MeV to compare theoretical codes. The target elements were chosen according to their relevance in cosmo chemistry and cosmo physics applications in which the production of cosmogenic nuclides in extraterrestrial matter, the target elements with atomic numbers < 29 and a few high-Z, such as Rb, Sr, Y, Zr, Te, Ba, Nb, etc. are needed. Heavy elements such as Ta, W, Hg, Pb, Bi, Tu and U are under discussion as spallation target materials for spallation neutron source and ADS applications.