This chapter considers the challenges posed by widespread transformation of behaviour to improve safety (particularly in terms of health and epidemic control), seeking to build on the experience of the “culture of food safety” and how it has profoundly transformed practices over the past couple of decades. Difficulties in achieving compliance with COVID-19 safety measures has shown the urgency of going beyond mere rule-setting and formal enforcement, and designing strategies and programmes to promote and achieve safer conduct at work and in social life. Understanding how culture change and safety culture have been systematically built up in the food sector through a combination of methods, systems, management and regulatory attention, can provide an important contribution.