Italy’s indicators of health system outcomes, quality and efficiency are uniformly impressive. Life expectancy, at 82.3 years, is the fifth highest in the OECD. Admission rates for asthma, chronic pulmonary disease and diabetes (markers of the quality of primary care) are amongst the very best in the OECD, and case-fatality after stroke or heart attack (markers of the quality of hospital care) are also well below OECD averages. Good health care is achieved at low cost – at USD 3 027 per capita, Italy spends much less than neighbouring countries such as Austria (USD 4 593), France (USD 4 121) or Germany (USD 4 650). These remarkable figures, however, mask profound regional differences. Five times as many children in Sicilia are admitted to hospital with an asthma attack than in Toscana, for example. Despite this, quality improvement and service redesign have taken a backseat as the economic crisis has hit. Financial consolidation has become an over-riding priority, even as health needs rapidly evolve. Dementia prevalence, healthy life years and daily activities limitations at age 65, for example, are all worse in Italy than OECD averages and Italian children are amongst the most overweight in the OECD. To address these challenges, Italy must urgently prioritise quality of its health care services alongside economic sustainability. Regional differences must be lessened, in part by giving central authorities a greater role in supporting regional monitoring of local performance. Proactive, co-ordinated care for people with complex needs must be delivered by a strengthened primary care sector. Fundamental to each of these steps will be ensuring that the knowledge and skills of the health care workforce are best matched to needs.