A well-designed national strategy on using public health genomics to strengthen public health and preventive care could make Chile a regional leader in this emerging field. Although the global trend of increasing use of genomic testing improving diagnosis and treatments for the sick and preventive measures for the healthy, Chile lacks of a national plan for implementing precision medicine in the clinical practice or public health policies. International efforts in OECD countries can provide good examples of government-industry system structures that have been successful in the expansion of genomics services, particularly for informing public health and preventive care. Regulation, rigorous empirical evidence, development of the genetics workforce, genetics education for health professionals and the public as well as careful attention to equitable service design is necessary to achieve widespread public health and preventive care applications in Chile.