COVID-19 has accelerated the digitalisation of working and social interactions. Global lockdowns to contain the pandemic have forced firms and workers to perform a wide range of daily functions through virtual means. This has led to greater uptake and acceptance of remote working, which will likely remain in the post-pandemic scenario. Governments and policy responses at the local and regional level can play a decisive role in supporting workers and firms in this transition. This report proposes a number of policy takeaways to guide short and long-term policy making to better prepare regions for what may be a ‘new normal’. The report relies on real-time subnational data to analyse changes in people’s mobility patterns and the determinants of remote working adoption across types of workers and regions. The report identifies different scenarios of settlement patterns that could emerge post-COVID-19, highlighting how changing patterns of work could impact on regional development and a range of policy areas, including infrastructure, healthcare and the environment.