Brazil currently faces a window of opportunity to implement its agenda of economic growth with social inclusion. Such a strategy requires, among others things, identifying potential complementarities between policies and creating the multi-level governance tools to co-ordinate policies in territories. Brazil’s institutional structure and multi-level governance framework are highly complex. Given its size, heterogeneity and constitutional framework, Brazil faces important multi-level governance challenges. This chapter explains how regional development policy could help to reach the national goal of growth with social inclusion. Then it will analyse these specific challenges for policy co-ordination, and highlight tools used in Brazil or in OECD countries that could be useful for overcoming these challenges.