Mark | Date Date | Title Title | |||
---|---|---|---|---|---|
08 Sept 2009 |
Test No. 441: Hershberger Bioassay in Rats
The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ... |
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16 Oct 2008 |
Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ... |
||||
15 Oct 2007 |
Test No. 426: Developmental Neurotoxicity Study
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ... |
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15 Oct 2007 |
Test No. 440: Uterotrophic Bioassay in Rodents
The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ... |
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11 Sept 2006 |
Summary of Considerations in the Report from the OECD Expert Groups on Short Term and Long Term Toxicology
|
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23 Nov 2004 |
Test No. 427: Skin Absorption: In Vivo Method
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ... |
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23 Nov 2004 |
Test No. 428: Skin Absorption: In Vitro Method
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ... |
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08 Feb 2002 |
Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ... |
||||
08 Feb 2002 |
Test No. 423: Acute Oral toxicity - Acute Toxic Class Method
This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method. |
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22 Jan 2001 |
Test No. 416: Two-Generation Reproduction Toxicity
This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and ... |
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21 Sept 1998 |
Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents
This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ... |
||||
21 Jul 1997 |
Test No. 424: Neurotoxicity Study in Rodents
This Test Guideline has been designed to obtain the information necessary to confirm or to further characterise the potential neurotoxicity of chemicals in adult animals. This Test Guideline is designed for use with the rat. It specifically ... |
||||
21 Jul 1997 |
Test No. 486: Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo
The purpose of the unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo is to identify substances that induce DNA repair after excision and removal of a stretch of DNA containing a region of damage induced by chemical substances ... |
||||
27 Jul 1995 |
Test No. 418: Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure
The test substance is administered orally in a single dose to domestic hens. The animals are observed for 21 days, then the remainder of the hens are killed and histopathological examination is undertaken. The young adult domestic laying hen (Gallus ... |
||||
27 Jul 1995 |
Test No. 419: Delayed Neurotoxicity of Organophosphorus Substances: 28-day Repeated Dose Study
This Test Guideline is used in the assessment and evaluation of the toxic effects of organophosporus substances. Daily doses of the test substance are administered orally (preferably by gavage or administration of gelatin capsules) to domestic ... |
||||
24 Feb 1987 |
Test No. 401: Acute Oral Toxicity
The OECD Guidelines for the Testing of Chemicals are a collection of about 100 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of ... |
||||
23 Oct 1986 |
Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells
The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ... |
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23 Oct 1986 |
Test No. 480: Genetic Toxicology: Saccharomyces cerevisiae, Gene Mutation Assay
This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ... |
||||
23 Oct 1986 |
Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay
This assay may be used to measure mitotic recombination (gene conversion or crossingover) in yeast, a eukaryotic micro-organism. Crossing-over is generally assayed by the production of recessive homozygous colonies or sectors produced in a ... |
||||
23 Oct 1986 |
Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ... |
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- OECD Guidelines for the Testing of Chemicals
- OECD Guidelines for the Testing of Chemicals, Section 4
OECD Guidelines for the Testing of Chemicals, Section 4
Health Effects
The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification, chemical registration and in chemical evaluation. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers health effects.
English Also available in: French
- ISSN: 20745788 (online)
- https://doi.org/10.1787/20745788
61 - 80 of 86 results
Test No. 441: Hershberger Bioassay in Rats
OECD
08 Sept 2009
The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ...
Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents
OECD
16 Oct 2008
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ...
Test No. 426: Developmental Neurotoxicity Study
OECD
15 Oct 2007
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...
Test No. 440: Uterotrophic Bioassay in Rodents
OECD
15 Oct 2007
The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ...
Summary of Considerations in the Report from the OECD Expert Groups on Short Term and Long Term Toxicology
OECD
11 Sept 2006
Test No. 427: Skin Absorption: In Vivo Method
OECD
23 Nov 2004
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Test No. 428: Skin Absorption: In Vitro Method
OECD
23 Nov 2004
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure
OECD
08 Feb 2002
A principle of the method is that in the main study only moderately toxic doses are used, and the administration of doses that are expected to be lethal should be avoided. This Guideline is intended primarily for use with rat. Groups of animals of a ...
Test No. 423: Acute Oral toxicity - Acute Toxic Class Method
OECD
08 Feb 2002
This is a test guideline for testing for Acute Oral Tosxidity using the Acute Toxic Class Method.
Test No. 416: Two-Generation Reproduction Toxicity
OECD
22 Jan 2001
This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and ...
Test No. 409: Repeated Dose 90-Day Oral Toxicity Study in Non-Rodents
OECD
21 Sept 1998
This method provides information on health hazard likely to arise from short-term exposure to test substance. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity has been ...
Test No. 424: Neurotoxicity Study in Rodents
OECD
21 Jul 1997
This Test Guideline has been designed to obtain the information necessary to confirm or to further characterise the potential neurotoxicity of chemicals in adult animals. This Test Guideline is designed for use with the rat. It specifically ...
Test No. 486: Unscheduled DNA Synthesis (UDS) Test with Mammalian Liver Cells in vivo
OECD
21 Jul 1997
The purpose of the unscheduled DNA synthesis (UDS) test with mammalian liver cells in vivo is to identify substances that induce DNA repair after excision and removal of a stretch of DNA containing a region of damage induced by chemical substances ...
Test No. 418: Delayed Neurotoxicity of Organophosphorus Substances Following Acute Exposure
OECD
27 Jul 1995
The test substance is administered orally in a single dose to domestic hens. The animals are observed for 21 days, then the remainder of the hens are killed and histopathological examination is undertaken. The young adult domestic laying hen (Gallus ...
Test No. 419: Delayed Neurotoxicity of Organophosphorus Substances: 28-day Repeated Dose Study
OECD
27 Jul 1995
This Test Guideline is used in the assessment and evaluation of the toxic effects of organophosporus substances. Daily doses of the test substance are administered orally (preferably by gavage or administration of gelatin capsules) to domestic ...
Test No. 401: Acute Oral Toxicity
OECD
24 Feb 1987
The OECD Guidelines for the Testing of Chemicals are a collection of about 100 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of ...
Test No. 479: Genetic Toxicology: In vitro Sister Chromatid Exchange Assay in Mammalian Cells
OECD
23 Oct 1986
The sister chromatid exchange (SCE) assay is a short-term test for the detection of reciprocal exchanges of DNA between two sister chromatids of a duplicating chromosome. Detection of SCEs requires some means of differentially labeling sister ...
This assay may be used to measure gene mutation in yeast, a eukaryotic micro-organism. Strains of Saccharomyces cerevisiae have been developed which detect forward or reverse mutations. A variety of haploid and diploid strains of the yeast can be ...
Test No. 481: Genetic Toxicology: Saacharomyces cerevisiae, Miotic Recombination Assay
OECD
23 Oct 1986
This assay may be used to measure mitotic recombination (gene conversion or crossingover) in yeast, a eukaryotic micro-organism. Crossing-over is generally assayed by the production of recessive homozygous colonies or sectors produced in a ...
Test No. 482: Genetic Toxicology: DNA Damage and Repair, Unscheduled DNA Synthesis in Mammalian Cells in vitro
OECD
23 Oct 1986
The Test Guideline for Unscheduled DNA Synthesis (UDS) in mammalian cells in vitro describes procedures utilizing primary cultures, human lymphocytes or established cell lines, to detect DNA repair synthesis after excision and removal of a stretch ...