Sélectionner | Date Date | Titre Titre | |||
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No. 47 | 01 Nov 2004 |
Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances
This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals. |
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No. 20 | 26 Nov 2004 |
Guidance Document for Neurotoxicity Testing
This document is intended to provide guidance on strategies and methods for testing of chemicals for potential neurotoxicity. The primary objective of this guidance is to ensure that necessary and sufficient data are obtained to enable adequate... |
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No. 34 | 18 Aug 2005 |
Guidance Document on the Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment
The purpose of this document is to provide guidance on issues related to the validation of new or updated test methods consistent with current approaches. This document provides a synopsis of the current state of test method validation, in what is a... |
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No. 53 | 02 May 2006 |
Guidance Document on Simulated Freshwater Lentic Field Tests (Outdoor Microcosms and Mesocosms)
Outdoor microcosms and mesocosms are useful in risk assessment when lower-tier and higher-tier laboratory studies (single-species and multi-species) indicate potential risks. They can be an important tool in bridging the gap between these studies and... |
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No. 54 | 09 May 2006 |
Current Approaches in the Statistical Analysis of Ecotoxicity Data
This document describes the main statistical methods used for analysis of data from ecotoxicological studies . |
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No. 55 | 31 Jul 2006 |
Detailed Review Paper on Aquatic Arthropods in Life Cycle Toxicity Tests with an Emphasis on Developmental, Reproductive and Endocrine Disruptive Effects
This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of aquatic invertebrate endocrinology, with a particular focus on the evaluation of possible developmental reproductive and endocrine disruptive... |
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No. 56 | 31 Jul 2006 |
Guidance Document on the Breakdown of Organic Matter in Litter Bags
The purpose of this Guidance Document is to identify possible and suitable approaches to the evaluation of chemicals impact, and in particular plant protection products’ impact, on soil organic matter breakdown. The test method and procedures... |
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No. 57 | 02 Aug 2006 |
Detailed Review Paper on Thyroid Hormone Disruption Assays
This document reviews the state of assays for thyroid toxicants across four vertebrate classes (fish, amphibians, birds and mammals) within the context of a thorough review of thyroid endocrinology across these taxa. Considering the similarity of the... |
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No. 31 | 13 Aug 2007 |
Detailed Review Paper on Cell Transformation Assays for Detection of Chemical Carcinogens
In vivo rodent models remain the only reliable way for experimental investigation of the carcinogenic risk of chemicals to humans, however, the rodent carcinogenicity assay is expensive and time-consuming. Several in vitro alternatives to... |
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No. 82 | 24 Oct 2007 |
Guidance Document on Amphibian Histology
The goals of this document are to provide guidance on the collection of morphologic data and preparation of thyroid tissues, from Xenopus laevis, for histopathological analysis to fulfill the needs of the Amphibian Metamorphosis Assay. This document... |
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No. 43 | 24 Jul 2008 |
Guidance Document on Mammalian Reproductive Toxicity Testing and Assessment
This document is intended to provide guidance on methodological aspects, interpretation of data and an overall approach for testing of chemicals for potential human and other mammalian reproductive toxicity. The document constitutes an essential... |
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No. 95 | 25 Jul 2008 |
Detailed Review Paper on Fish Life-Cycle Tests
The principal purpose of this Detailed Review Paper (DRP) is to define the basis, objectives and conduct of fish life-cycle tests for the effects of endocrine disrupting chemicals (EDCs). The main focus is on four species of fish (fathead minnow... |
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No. 97 | 29 Jul 2008 |
Guidance Document on Magnitude of Pesticide Residues in Processed Commodities
A wide range of raw agricultural commodities (RAC) are processed before consumption by the public. In fact, many RACs are consumed in multiple processed forms [e.g. grapes (RAC), raisins, grape juice, wine; potato (RAC), chips, cooked, baked and... |
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No. 98 | 22 Oct 2008 |
Considerations Regarding Applicability of the Guidance on Transformation/Dissolution of Metals and Metal Compounds in Aqueous Media (Transformation/Dissolution Protocol)
The aim of this report is to present further considerations on the applicability of the Guidance on Transformation/Dissolution of Metals and Metal Compounds in Aquatic Media (Transformation/Dissolution Protocol: abbreviated to T/DP)1 to the... |
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No. 103 | 23 Jul 2009 |
Detailed Review Paper on Transgenic Rodent Mutation Assays
Induced chromosomal and gene mutations cause genetic diseases, birth defects and other disease conditions and play a role in carcinogenesis. While it is widely accepted that in vivo mutation assays are more relevant to the human condition than in... |
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No. 106 | 28 Jul 2009 |
Guidance Document for Histologic Evaluation of Endocrine and Reproductive Tests in Rodents
This Guidance Document has been prepared to provide the pathologist reading slides from endocrine and reproductive studies (eg the updated TG407 and longer studies) with sufficient information to be able to identify the often subtle histopathologic... |
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No. 126 | 31 May 2010 |
Short Guidance on the Treshold Approach for Acute Fish Toxicity
This document presents a short guidance on the Threshold Approach for Acute Fish Toxicity. In the interest of animal welfare and efficient use of resources, it is important to avoid the unnecessary use of animals whenever possible. In the field of... |
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No. 123 | 31 May 2010 |
Guidance Document on the Diagnosis of Endocrine-related Histopathology in Fish Gonads
Exposure of fathead minnow (Pimephales promelas), Japanese medaka (Oryzias latipes) and zebrafish (Danio rerio) to endocrine disrupting chemicals may result in histopathological alterations of gonadal structure and microarchitecture. The diagnosis of... |
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No. 125 | 01 Jun 2010 |
Guidance Document on Histopathology for Inhalation Toxicity Studies, Supporting TG 412 (Subacute Inhalation Toxicity: 28-day Study) and TG 413 (Subchronic Inhalation Toxicity: 90-day Study)
The purpose of this Guidance Document (GD) is to provide pathologists, toxicologists, and associated scientists with recommended guidelines for performing the pathology tasks required by the specifications of TG 412 and 413, and for optimising the... |
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No. 124 | 07 Jun 2010 |
Guidance for the Derivation of an Acute Reference Dose
The objective of this document is to provide guidance on how to derive an Acute Reference Dose (ARfD). It outlines a stepwise approach on how to best use all available toxicological data, and what to do if more data are needed on the refinement of... |
OECD Series on Testing and Assessment
This Series includes publications related to testing and assessment of chemicals; some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance documents, detailed review papers).
Anglais
- ISSN : 20777876 (en ligne)
- https://doi.org/10.1787/20777876
41 - 60 of 144 results
Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances
OCDE
01 Nov 2004
This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of fish screening assays for chemicals active at the endocrine level on the reproductive system of test animals.
Guidance Document for Neurotoxicity Testing
OCDE
26 Nov 2004
This document is intended to provide guidance on strategies and methods for testing of chemicals for potential neurotoxicity. The primary objective of this guidance is to ensure that necessary and sufficient data are obtained to enable adequate...
Guidance Document on the Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment
OCDE
18 Aug 2005
The purpose of this document is to provide guidance on issues related to the validation of new or updated test methods consistent with current approaches. This document provides a synopsis of the current state of test method validation, in what is a...
Guidance Document on Simulated Freshwater Lentic Field Tests (Outdoor Microcosms and Mesocosms)
OCDE
02 May 2006
Outdoor microcosms and mesocosms are useful in risk assessment when lower-tier and higher-tier laboratory studies (single-species and multi-species) indicate potential risks. They can be an important tool in bridging the gap between these studies and...
Current Approaches in the Statistical Analysis of Ecotoxicity Data
OCDE
09 May 2006
This document describes the main statistical methods used for analysis of data from ecotoxicological studies .
Detailed Review Paper on Aquatic Arthropods in Life Cycle Toxicity Tests with an Emphasis on Developmental, Reproductive and Endocrine Disruptive Effects
OCDE
31 Jul 2006
This Detailed Review Paper (DRP) is intended to provide the current state-of-the-knowledge in the area of aquatic invertebrate endocrinology, with a particular focus on the evaluation of possible developmental reproductive and endocrine disruptive...
Guidance Document on the Breakdown of Organic Matter in Litter Bags
OCDE
31 Jul 2006
The purpose of this Guidance Document is to identify possible and suitable approaches to the evaluation of chemicals impact, and in particular plant protection products’ impact, on soil organic matter breakdown. The test method and procedures...
Detailed Review Paper on Thyroid Hormone Disruption Assays
OCDE
02 Aug 2006
This document reviews the state of assays for thyroid toxicants across four vertebrate classes (fish, amphibians, birds and mammals) within the context of a thorough review of thyroid endocrinology across these taxa. Considering the similarity of the...
Detailed Review Paper on Cell Transformation Assays for Detection of Chemical Carcinogens
OCDE
13 Aug 2007
In vivo rodent models remain the only reliable way for experimental investigation of the carcinogenic risk of chemicals to humans, however, the rodent carcinogenicity assay is expensive and time-consuming. Several in vitro alternatives to...
Guidance Document on Amphibian Histology
OCDE
24 Oct 2007
The goals of this document are to provide guidance on the collection of morphologic data and preparation of thyroid tissues, from Xenopus laevis, for histopathological analysis to fulfill the needs of the Amphibian Metamorphosis Assay. This document...
This document is intended to provide guidance on methodological aspects, interpretation of data and an overall approach for testing of chemicals for potential human and other mammalian reproductive toxicity. The document constitutes an essential...
Detailed Review Paper on Fish Life-Cycle Tests
OCDE
25 Jul 2008
The principal purpose of this Detailed Review Paper (DRP) is to define the basis, objectives and conduct of fish life-cycle tests for the effects of endocrine disrupting chemicals (EDCs). The main focus is on four species of fish (fathead minnow...
A wide range of raw agricultural commodities (RAC) are processed before consumption by the public. In fact, many RACs are consumed in multiple processed forms [e.g. grapes (RAC), raisins, grape juice, wine; potato (RAC), chips, cooked, baked and...
The aim of this report is to present further considerations on the applicability of the Guidance on Transformation/Dissolution of Metals and Metal Compounds in Aquatic Media (Transformation/Dissolution Protocol: abbreviated to T/DP)1 to the...
Detailed Review Paper on Transgenic Rodent Mutation Assays
OCDE
23 Jul 2009
Induced chromosomal and gene mutations cause genetic diseases, birth defects and other disease conditions and play a role in carcinogenesis. While it is widely accepted that in vivo mutation assays are more relevant to the human condition than in...
Guidance Document for Histologic Evaluation of Endocrine and Reproductive Tests in Rodents
OCDE
28 Jul 2009
This Guidance Document has been prepared to provide the pathologist reading slides from endocrine and reproductive studies (eg the updated TG407 and longer studies) with sufficient information to be able to identify the often subtle histopathologic...
Short Guidance on the Treshold Approach for Acute Fish Toxicity
OCDE
31 May 2010
This document presents a short guidance on the Threshold Approach for Acute Fish Toxicity. In the interest of animal welfare and efficient use of resources, it is important to avoid the unnecessary use of animals whenever possible. In the field of...
Guidance Document on the Diagnosis of Endocrine-related Histopathology in Fish Gonads
OCDE
31 May 2010
Exposure of fathead minnow (Pimephales promelas), Japanese medaka (Oryzias latipes) and zebrafish (Danio rerio) to endocrine disrupting chemicals may result in histopathological alterations of gonadal structure and microarchitecture. The diagnosis of...
The purpose of this Guidance Document (GD) is to provide pathologists, toxicologists, and associated scientists with recommended guidelines for performing the pathology tasks required by the specifications of TG 412 and 413, and for optimising the...
Guidance for the Derivation of an Acute Reference Dose
OCDE
07 Jun 2010
The objective of this document is to provide guidance on how to derive an Acute Reference Dose (ARfD). It outlines a stepwise approach on how to best use all available toxicological data, and what to do if more data are needed on the refinement of...