Sélectionner | Date Date | Titre Titre | |||
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No. 122 | 07 Jun 2010 |
Guidance Document on the Determination of the Toxicity of a Test Chemical to the Dung Beetle Aphodius Constans
This document presents the OECD Guidance Document on the Determination of the Toxicity of a Test Chemical to the Dung Beetle Aphodius Constans. This test method is designed to assess the effects of a test chemical, e.g. veterinary pharmaceuticals, to... |
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No. 129 | 20 Jul 2010 |
Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systematic Toxicity Tests
This Guidance Document describes methods to determine the in vitro basal cytotoxicity of test substances using NRU assays and the use of the in vitro data to determine starting doses for in vivo acute oral systemic toxicity tests. The NRU assay is... |
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No. 135 | 16 Sept 2010 |
Detailed Review Paper on Environmental Endocrine Disruptor Screening: The Use of Estrogen and Androgen Receptor Binding and Transactivation Assays in Fish
The current Detailed Review Paper (DRP) has been developed under the Validation Management Groups for Ecotoxicity Testing (VMGeco) and Non-Animal testing (VMG NA). The DRP focuses on estrogen and androgen in vitro receptor and transcriptional... |
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No. 117 | 27 Jul 2011 |
Guidance Document 117 on the Current Implementation of Internal Triggers in Test Guideline 443 for an Extended One Generation Reproductive Toxicity Study, in the United States and Canada
This document constitutes an essential supplement to OECD Test Guideline 443 (EOGRTS) to describe the use of data gathered within the study to determine if a second generation should be produced. However, as a starting point, available mode of action... |
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No. 173 | 01 Aug 2012 |
Performance Standards for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Agonists for TG 455
This document includes the Performance Standards (PS) for stably transfected transactivation in vitroassays to detect estrogen receptor (ER) antagonists. These PS accompany the Performance-Based Test Guideline (PBTG) for Transfected Transactivation... |
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No. 178 | 21 Aug 2012 |
Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors
This paper provides methods for both the mechanistic evaluation of the action of Endocrine Disrupter Chemicals (EDCs). |
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No. 185 | 25 Apr 2013 |
Guidance Document for Exposure Assessment Based on Environmental Monitoring Data
This document provides guidance for performing an exposure assessment – for humans and the environment – based on environmental monitoring data. It covers topics such as environmental levels and distribution of contaminants, ways of using monitoring... |
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No. 201 | 11 Jul 2014 |
Guidance Document on Harpacticoid Copepod Development and Reproduction Test with Amphiascus
This Guidance Document describes test procedures for measuring the (sub)chronic effects of chemicals on an estuarine/marine harpacticoid copepod species under semistatic conditions; the biological endpoints include survival and development rates of... |
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No. 207 | 11 Jul 2014 |
New Scoping Document on in vitro and ex vivo Assays for the Identification of Modulators of Thyroid Hormone Signalling
This scoping document aims at bringing forward relevant in vitro and ex vivo thyroid assays to the attention of OECD member countries, to provide recommendations for their development/use, and also, to identify aspects/blocks of the thyroid... |
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No. 69 | 03 Sept 2014 |
Guidance Document on the Validation of (Quantitative) Structure-Activity Relationship [(Q)SAR] Models
This document presents principles and helpful guides for validating (Q)SAR technology for a variety of applications. |
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No. 97 | 03 Sept 2014 |
Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors
This Detailed Review Paper describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations. |
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No. 75 | 03 Sept 2014 |
Guidance Document on the Honey Bee (Apis Mellifera L.) Brood test Under Semi-field Conditions
The method described in this guidance document assesses the effects of plant protection products (PPPs), and has been validated using the active Fenoxycarb, which is known to act as an insect growth regulator (IGR), to the honey bee brood (Apis... |
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No. 80 | 03 Sept 2014 |
Guidance on Grouping of Chemicals
This guidance document provides guidance for assessing the hazards of chemical substances while gaining efficiencies and improving animal welfare. The approach described in this guidance document is to consider closely related chemicals as a group,... |
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No. 177 | 03 Sept 2014 |
Fish Toxicity Testing Framework
This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant. |
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No. 168 | 03 Sept 2014 |
The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins
This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies... |
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No. 121 | 03 Sept 2014 |
Detailed Review Paper (DRP) on Molluscs Life-cycle Toxicity Testing
This paper reviews what is known about the responses of molluscs to endocrine disrupting chemicals (EDCs), to consider whether it would be desirable and feasible to standardise mollusc-based partial- and full-lifecycle tests that are sensitive to... |
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No. 116 | 03 Sept 2014 |
Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453
This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453. |
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No. 102 | 03 Sept 2014 |
The Guidance Document for Using the OECD (Q)SAR Application Toolbox to Develop Chemical Categories According to the OECD Guidance on Grouping Chemicals
This document provides guidance on how to use the OECD (Q)SAR Application Toolbox to build chemical categories according to the OECD Guidance on Grouping of Chemicals. It is part of an overall effort to provide guidance on the use of the (Q)SAR... |
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No. 214 | 22 May 2015 |
Guidance Document on the In Vitro Syrian Hamster Embryo (SHE) Cell Transformation Assay
This document presents guidance for conducting the Syrian Hamster Embryo Cells Transformation Assay (SHE CTA). The purpose of this Guidance document is to allow the regulatory community to use the described method as part of a weight of evidence... |
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No. 213 | 22 May 2015 |
Performance Standards for Assessment of Proposed Similar or Modified In Vitro Skin Sensitisation ARE-NRF2 Luciferase Test Methods
The purpose of PS is to provide the basis by which new or modified test methods, both proprietary (i.e. copyrighted, trademarked, registered) and non-proprietary can demonstrate to have sufficient reliability and relevance for specific testing... |
OECD Series on Testing and Assessment
This Series includes publications related to testing and assessment of chemicals; some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance documents, detailed review papers).
Anglais
- ISSN : 20777876 (en ligne)
- https://doi.org/10.1787/20777876
61 - 80 of 144 results
Guidance Document on the Determination of the Toxicity of a Test Chemical to the Dung Beetle Aphodius Constans
OCDE
07 Jun 2010
This document presents the OECD Guidance Document on the Determination of the Toxicity of a Test Chemical to the Dung Beetle Aphodius Constans. This test method is designed to assess the effects of a test chemical, e.g. veterinary pharmaceuticals, to...
Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systematic Toxicity Tests
OCDE
20 Jul 2010
This Guidance Document describes methods to determine the in vitro basal cytotoxicity of test substances using NRU assays and the use of the in vitro data to determine starting doses for in vivo acute oral systemic toxicity tests. The NRU assay is...
Detailed Review Paper on Environmental Endocrine Disruptor Screening: The Use of Estrogen and Androgen Receptor Binding and Transactivation Assays in Fish
OCDE
16 Sept 2010
The current Detailed Review Paper (DRP) has been developed under the Validation Management Groups for Ecotoxicity Testing (VMGeco) and Non-Animal testing (VMG NA). The DRP focuses on estrogen and androgen in vitro receptor and transcriptional...
This document constitutes an essential supplement to OECD Test Guideline 443 (EOGRTS) to describe the use of data gathered within the study to determine if a second generation should be produced. However, as a starting point, available mode of action...
Performance Standards for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Agonists for TG 455
OCDE
01 Aug 2012
This document includes the Performance Standards (PS) for stably transfected transactivation in vitroassays to detect estrogen receptor (ER) antagonists. These PS accompany the Performance-Based Test Guideline (PBTG) for Transfected Transactivation...
This paper provides methods for both the mechanistic evaluation of the action of Endocrine Disrupter Chemicals (EDCs).
This document provides guidance for performing an exposure assessment – for humans and the environment – based on environmental monitoring data. It covers topics such as environmental levels and distribution of contaminants, ways of using monitoring...
Guidance Document on Harpacticoid Copepod Development and Reproduction Test with Amphiascus
OCDE
11 Jul 2014
This Guidance Document describes test procedures for measuring the (sub)chronic effects of chemicals on an estuarine/marine harpacticoid copepod species under semistatic conditions; the biological endpoints include survival and development rates of...
New Scoping Document on in vitro and ex vivo Assays for the Identification of Modulators of Thyroid Hormone Signalling
OCDE
11 Jul 2014
This scoping document aims at bringing forward relevant in vitro and ex vivo thyroid assays to the attention of OECD member countries, to provide recommendations for their development/use, and also, to identify aspects/blocks of the thyroid...
Guidance Document on the Validation of (Quantitative) Structure-Activity Relationship [(Q)SAR] Models
OCDE
03 Sept 2014
This document presents principles and helpful guides for validating (Q)SAR technology for a variety of applications.
Detailed Review Paper on the Use of Metabolising Systems for In Vitro Testing of Endocrine Disruptors
OCDE
03 Sept 2014
This Detailed Review Paper describes some endocrine pathways that have been shown to be susceptible to environmental endocrine disruption and whose disruption could contribute to increasing incidents of some disorders in humans and wildlife populations.
Guidance Document on the Honey Bee (Apis Mellifera L.) Brood test Under Semi-field Conditions
OCDE
03 Sept 2014
The method described in this guidance document assesses the effects of plant protection products (PPPs), and has been validated using the active Fenoxycarb, which is known to act as an insect growth regulator (IGR), to the honey bee brood (Apis...
Guidance on Grouping of Chemicals
OCDE
03 Sept 2014
This guidance document provides guidance for assessing the hazards of chemical substances while gaining efficiencies and improving animal welfare. The approach described in this guidance document is to consider closely related chemicals as a group,...
Fish Toxicity Testing Framework
OCDE
03 Sept 2014
This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant.
The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins
OCDE
03 Sept 2014
This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies...
Detailed Review Paper (DRP) on Molluscs Life-cycle Toxicity Testing
OCDE
03 Sept 2014
This paper reviews what is known about the responses of molluscs to endocrine disrupting chemicals (EDCs), to consider whether it would be desirable and feasible to standardise mollusc-based partial- and full-lifecycle tests that are sensitive to...
Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453
OCDE
03 Sept 2014
This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
The Guidance Document for Using the OECD (Q)SAR Application Toolbox to Develop Chemical Categories According to the OECD Guidance on Grouping Chemicals
OCDE
03 Sept 2014
This document provides guidance on how to use the OECD (Q)SAR Application Toolbox to build chemical categories according to the OECD Guidance on Grouping of Chemicals. It is part of an overall effort to provide guidance on the use of the (Q)SAR...
Guidance Document on the In Vitro Syrian Hamster Embryo (SHE) Cell Transformation Assay
OCDE
22 May 2015
This document presents guidance for conducting the Syrian Hamster Embryo Cells Transformation Assay (SHE CTA). The purpose of this Guidance document is to allow the regulatory community to use the described method as part of a weight of evidence...
Performance Standards for Assessment of Proposed Similar or Modified In Vitro Skin Sensitisation ARE-NRF2 Luciferase Test Methods
OCDE
22 May 2015
The purpose of PS is to provide the basis by which new or modified test methods, both proprietary (i.e. copyrighted, trademarked, registered) and non-proprietary can demonstrate to have sufficient reliability and relevance for specific testing...