Sélectionner | Date Date | Titre Titre | |||
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No. 311 | 22 Oct 2019 |
Guiding Principles and Key Elements for Establishing a Weight of Evidence for Chemical Assessment
This document is intended to provide universal Guiding Principles that should be considered when developing or augmenting systematic approaches to Weight of Evidence (WoE) for chemical evaluation and Key Elements to formulating a systematic approach... |
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No. 259 | 13 Apr 2017 |
Guidance on the Incorporation of Bioavailability Concepts for Assessing the Chemical Ecological Risk and/or Environmental Threshold Values of Metals and Inorganic Metal Compounds
Several models, tools and methods have been published in the past 20 years to include bioavailability in risk assessment and several OECD member countries already have developed frameworks and published guidance documents for taking metal... |
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No. 212 | 13 Apr 2017 |
Guidance on Selecting a Strategy for Assessing the Ecological risk of Organometallic and Organic Metal Salt Substances based on their Environmental Fate
In this document a strategy is presented to facilitate the ecological risk assessment of organometallic compounds (OM) and organic metal salts (OMS), outlining key steps that are based on elucidation of the fate of these substances in the... |
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No. 194 | 13 Apr 2017 |
Guidance on Grouping of Chemicals, Second Edition
This guidance document is part of the OECD effort to provide guidance for assessing the hazards of chemical substances while gaining efficiencies and improving animal welfare. The approach described in this guidance document is to consider closely... |
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No. 80 | 03 Sept 2014 |
Guidance on Grouping of Chemicals
This guidance document provides guidance for assessing the hazards of chemical substances while gaining efficiencies and improving animal welfare. The approach described in this guidance document is to consider closely related chemicals as a group,... |
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No. 124 | 07 Jun 2010 |
Guidance for the Derivation of an Acute Reference Dose
The objective of this document is to provide guidance on how to derive an Acute Reference Dose (ARfD). It outlines a stepwise approach on how to best use all available toxicological data, and what to do if more data are needed on the refinement of... |
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No. 331 | 03 Feb 2021 |
Guidance document on the characterisation, validation and reporting of Physiologically Based Kinetic (PBK) models for regulatory purposes
The fields of toxicology and chemical risk assessment evaluate the safety of chemicals for humans the environment. Increasingly, modern methods seek to reduce the use of animals in chemical safety testing and predictive toxicology. In this context,... |
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No. 32 | 10 May 2002 |
Guidance Notes for Analysis and Evaluation of Repeat-Dose Toxicity Studies
This document presents a general guide to the analysis and evaluation of data from studies involving repeated exposures of toxicity test species to pesticides and other chemicals. |
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No. 35 | 12 Dec 2002 |
Guidance Notes for Analysis and Evaluation of Chronic Toxicity and Carcinogenicity Studies
These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information. |
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No. 69 | 03 Sept 2014 |
Guidance Document on the Validation of (Quantitative) Structure-Activity Relationship [(Q)SAR] Models
This document presents principles and helpful guides for validating (Q)SAR technology for a variety of applications. |
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No. 34 | 18 Aug 2005 |
Guidance Document on the Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment
The purpose of this document is to provide guidance on issues related to the validation of new or updated test methods consistent with current approaches. This document provides a synopsis of the current state of test method validation, in what is a... |
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No. 71 | 19 Jul 2017 |
Guidance Document on the Uterothrophic Bioassay - Procedure to Test for Antioestrogenicity
This Guidance document focuses on the antioestrogenic protocol; it is the outcome of the experience gained during the validation test programme and the results obtained thereby with the use of a strong oestrogen receptor antagonist. Due to... |
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No. 27 | 10 May 2002 |
Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment
This document provides a description of a Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment and guidance to how the system will work. |
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No. 45 | 01 Nov 2004 |
Guidance Document on the Use of Multimedia Models for Estimating Overall Environmental Persistance and Long-Range Transport
This Guidance Document concerns using multimedia models, i.e. generic evaluative models that can calculate overall environmental persistence (Pov) and potential for long-range transport (LTRP) covering multiple compartments such as air, water,... |
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No. 255 | 13 Apr 2017 |
Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment
With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to... |
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No. 256 | 11 Jul 2017 |
Guidance Document on the Reporting of Defined Approaches and Individual Information Sources to be Used within Integrated Approaches to Testing and Assessment (IATA) for Skin Sensitisation
With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides guidance on the reporting of defined approaches to testing... |
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No. 19 | 10 May 2002 |
Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation
The purpose of this Guidance Document is to apply the principles of the Three Rs to the use of animals in regulatory toxicity tests. |
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No. 214 | 22 May 2015 |
Guidance Document on the In Vitro Syrian Hamster Embryo (SHE) Cell Transformation Assay
This document presents guidance for conducting the Syrian Hamster Embryo Cells Transformation Assay (SHE CTA). The purpose of this Guidance document is to allow the regulatory community to use the described method as part of a weight of evidence... |
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No. 75 | 03 Sept 2014 |
Guidance Document on the Honey Bee (Apis Mellifera L.) Brood test Under Semi-field Conditions
The method described in this guidance document assesses the effects of plant protection products (PPPs), and has been validated using the active Fenoxycarb, which is known to act as an insect growth regulator (IGR), to the honey bee brood (Apis... |
|||
No. 123 | 31 May 2010 |
Guidance Document on the Diagnosis of Endocrine-related Histopathology in Fish Gonads
Exposure of fathead minnow (Pimephales promelas), Japanese medaka (Oryzias latipes) and zebrafish (Danio rerio) to endocrine disrupting chemicals may result in histopathological alterations of gonadal structure and microarchitecture. The diagnosis of... |
OECD Series on Testing and Assessment
This Series includes publications related to testing and assessment of chemicals; some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance documents, detailed review papers).
Anglais
- ISSN : 20777876 (en ligne)
- https://doi.org/10.1787/20777876
41 - 60 of 144 results
Guiding Principles and Key Elements for Establishing a Weight of Evidence for Chemical Assessment
OCDE
22 Oct 2019
This document is intended to provide universal Guiding Principles that should be considered when developing or augmenting systematic approaches to Weight of Evidence (WoE) for chemical evaluation and Key Elements to formulating a systematic approach...
Several models, tools and methods have been published in the past 20 years to include bioavailability in risk assessment and several OECD member countries already have developed frameworks and published guidance documents for taking metal...
Guidance on Selecting a Strategy for Assessing the Ecological risk of Organometallic and Organic Metal Salt Substances based on their Environmental Fate
OCDE
13 Apr 2017
In this document a strategy is presented to facilitate the ecological risk assessment of organometallic compounds (OM) and organic metal salts (OMS), outlining key steps that are based on elucidation of the fate of these substances in the...
Guidance on Grouping of Chemicals, Second Edition
OCDE
13 Apr 2017
This guidance document is part of the OECD effort to provide guidance for assessing the hazards of chemical substances while gaining efficiencies and improving animal welfare. The approach described in this guidance document is to consider closely...
Guidance on Grouping of Chemicals
OCDE
03 Sept 2014
This guidance document provides guidance for assessing the hazards of chemical substances while gaining efficiencies and improving animal welfare. The approach described in this guidance document is to consider closely related chemicals as a group,...
Guidance for the Derivation of an Acute Reference Dose
OCDE
07 Jun 2010
The objective of this document is to provide guidance on how to derive an Acute Reference Dose (ARfD). It outlines a stepwise approach on how to best use all available toxicological data, and what to do if more data are needed on the refinement of...
Guidance document on the characterisation, validation and reporting of Physiologically Based Kinetic (PBK) models for regulatory purposes
OCDE
03 Feb 2021
The fields of toxicology and chemical risk assessment evaluate the safety of chemicals for humans the environment. Increasingly, modern methods seek to reduce the use of animals in chemical safety testing and predictive toxicology. In this context,...
This document presents a general guide to the analysis and evaluation of data from studies involving repeated exposures of toxicity test species to pesticides and other chemicals.
Guidance Notes for Analysis and Evaluation of Chronic Toxicity and Carcinogenicity Studies
OCDE
12 Dec 2002
These Guidance Notes outline core concepts in order to obviate the need to consult large numbers of text books, while still pointing the reader to sources of more detailed or specific information.
Guidance Document on the Validation of (Quantitative) Structure-Activity Relationship [(Q)SAR] Models
OCDE
03 Sept 2014
This document presents principles and helpful guides for validating (Q)SAR technology for a variety of applications.
Guidance Document on the Validation and International Acceptance of New or Updated Test Methods for Hazard Assessment
OCDE
18 Aug 2005
The purpose of this document is to provide guidance on issues related to the validation of new or updated test methods consistent with current approaches. This document provides a synopsis of the current state of test method validation, in what is a...
Guidance Document on the Uterothrophic Bioassay - Procedure to Test for Antioestrogenicity
OCDE
19 Jul 2017
This Guidance document focuses on the antioestrogenic protocol; it is the outcome of the experience gained during the validation test programme and the results obtained thereby with the use of a strong oestrogen receptor antagonist. Due to...
Guidance Document on the Use of the Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment
OCDE
10 May 2002
This document provides a description of a Harmonised System for the Classification of Chemicals which are Hazardous for the Aquatic Environment and guidance to how the system will work.
Guidance Document on the Use of Multimedia Models for Estimating Overall Environmental Persistance and Long-Range Transport
OCDE
01 Nov 2004
This Guidance Document concerns using multimedia models, i.e. generic evaluative models that can calculate overall environmental persistence (Pov) and potential for long-range transport (LTRP) covering multiple compartments such as air, water,...
Guidance Document on the Reporting of Defined Approaches to be Used Within Integrated Approaches to Testing and Assessment
OCDE
13 Apr 2017
With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides a set of principles for reporting defined approaches to...
With a view to assisting the evaluation of integrated approaches to testing and assessment (IATA) in regulatory decision-making within OECD Member Countries, this guidance document provides guidance on the reporting of defined approaches to testing...
Guidance Document on the Recognition, Assessment and Use of Clinical Signs as Human Endpoints for Experimental Animals Used in Safety Evaluation
OCDE
10 May 2002
The purpose of this Guidance Document is to apply the principles of the Three Rs to the use of animals in regulatory toxicity tests.
Guidance Document on the In Vitro Syrian Hamster Embryo (SHE) Cell Transformation Assay
OCDE
22 May 2015
This document presents guidance for conducting the Syrian Hamster Embryo Cells Transformation Assay (SHE CTA). The purpose of this Guidance document is to allow the regulatory community to use the described method as part of a weight of evidence...
Guidance Document on the Honey Bee (Apis Mellifera L.) Brood test Under Semi-field Conditions
OCDE
03 Sept 2014
The method described in this guidance document assesses the effects of plant protection products (PPPs), and has been validated using the active Fenoxycarb, which is known to act as an insect growth regulator (IGR), to the honey bee brood (Apis...
Guidance Document on the Diagnosis of Endocrine-related Histopathology in Fish Gonads
OCDE
31 May 2010
Exposure of fathead minnow (Pimephales promelas), Japanese medaka (Oryzias latipes) and zebrafish (Danio rerio) to endocrine disrupting chemicals may result in histopathological alterations of gonadal structure and microarchitecture. The diagnosis of...