Sélectionner | Date Date | Titre Titre | |||
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No. 177 | 03 Sept 2014 |
Fish Toxicity Testing Framework
This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant. |
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No. 174 | 21 Aug 2015 |
Performance Standards For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Antagonists - Second edition
This document includes the Performance Standards (PS) for stably transfected transactivation in vitroassays to detect estrogen receptor (ER) antagonists. These PS accompany the Performance-Based Test Guideline (PBTG) for Transfected Transactivation... |
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No. 173 | 01 Aug 2012 |
Performance Standards for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Agonists for TG 455
This document includes the Performance Standards (PS) for stably transfected transactivation in vitroassays to detect estrogen receptor (ER) antagonists. These PS accompany the Performance-Based Test Guideline (PBTG) for Transfected Transactivation... |
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No. 168 | 03 Sept 2014 |
The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins
This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies... |
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No. 160 | 06 Jul 2018 |
Guidance Document on the Collection of Eyes Tissues for Histological Evaluation and Collection of Data - Second Edition
This Guidance Document accompanies the OECD Test Guideline (TG) 437 on the bovine corneal opacity and permeability (BCOP) test method and TG 438 on the isolated chicken eye (ICE) test method. It provides users with guidelines for collecting... |
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No. 150 | 03 Sept 2018 |
Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption
This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals. |
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No. 148 | 08 Aug 2017 |
Guidance Document on the Androgenised Female Stickleback Screen
This guidance document describes an in vivo screening assay where sexually mature female sticklebacks are exposed to suspected anti-androgenic chemicals during a limited part of their life-cycle (21 days). The AFFS can detect both androgens and... |
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No. 135 | 16 Sept 2010 |
Detailed Review Paper on Environmental Endocrine Disruptor Screening: The Use of Estrogen and Androgen Receptor Binding and Transactivation Assays in Fish
The current Detailed Review Paper (DRP) has been developed under the Validation Management Groups for Ecotoxicity Testing (VMGeco) and Non-Animal testing (VMG NA). The DRP focuses on estrogen and androgen in vitro receptor and transcriptional... |
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No. 129 | 20 Jul 2010 |
Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systematic Toxicity Tests
This Guidance Document describes methods to determine the in vitro basal cytotoxicity of test substances using NRU assays and the use of the in vitro data to determine starting doses for in vivo acute oral systemic toxicity tests. The NRU assay is... |
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No. 126 | 31 May 2010 |
Short Guidance on the Treshold Approach for Acute Fish Toxicity
This document presents a short guidance on the Threshold Approach for Acute Fish Toxicity. In the interest of animal welfare and efficient use of resources, it is important to avoid the unnecessary use of animals whenever possible. In the field of... |
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No. 125 | 01 Jun 2010 |
Guidance Document on Histopathology for Inhalation Toxicity Studies, Supporting TG 412 (Subacute Inhalation Toxicity: 28-day Study) and TG 413 (Subchronic Inhalation Toxicity: 90-day Study)
The purpose of this Guidance Document (GD) is to provide pathologists, toxicologists, and associated scientists with recommended guidelines for performing the pathology tasks required by the specifications of TG 412 and 413, and for optimising the... |
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No. 124 | 07 Jun 2010 |
Guidance for the Derivation of an Acute Reference Dose
The objective of this document is to provide guidance on how to derive an Acute Reference Dose (ARfD). It outlines a stepwise approach on how to best use all available toxicological data, and what to do if more data are needed on the refinement of... |
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No. 123 | 31 May 2010 |
Guidance Document on the Diagnosis of Endocrine-related Histopathology in Fish Gonads
Exposure of fathead minnow (Pimephales promelas), Japanese medaka (Oryzias latipes) and zebrafish (Danio rerio) to endocrine disrupting chemicals may result in histopathological alterations of gonadal structure and microarchitecture. The diagnosis of... |
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No. 122 | 07 Jun 2010 |
Guidance Document on the Determination of the Toxicity of a Test Chemical to the Dung Beetle Aphodius Constans
This document presents the OECD Guidance Document on the Determination of the Toxicity of a Test Chemical to the Dung Beetle Aphodius Constans. This test method is designed to assess the effects of a test chemical, e.g. veterinary pharmaceuticals, to... |
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No. 121 | 03 Sept 2014 |
Detailed Review Paper (DRP) on Molluscs Life-cycle Toxicity Testing
This paper reviews what is known about the responses of molluscs to endocrine disrupting chemicals (EDCs), to consider whether it would be desirable and feasible to standardise mollusc-based partial- and full-lifecycle tests that are sensitive to... |
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No. 117 | 27 Jul 2011 |
Guidance Document 117 on the Current Implementation of Internal Triggers in Test Guideline 443 for an Extended One Generation Reproductive Toxicity Study, in the United States and Canada
This document constitutes an essential supplement to OECD Test Guideline 443 (EOGRTS) to describe the use of data gathered within the study to determine if a second generation should be produced. However, as a starting point, available mode of action... |
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No. 116 | 03 Sept 2014 |
Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453
This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453. |
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No. 106 | 28 Jul 2009 |
Guidance Document for Histologic Evaluation of Endocrine and Reproductive Tests in Rodents
This Guidance Document has been prepared to provide the pathologist reading slides from endocrine and reproductive studies (eg the updated TG407 and longer studies) with sufficient information to be able to identify the often subtle histopathologic... |
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No. 103 | 23 Jul 2009 |
Detailed Review Paper on Transgenic Rodent Mutation Assays
Induced chromosomal and gene mutations cause genetic diseases, birth defects and other disease conditions and play a role in carcinogenesis. While it is widely accepted that in vivo mutation assays are more relevant to the human condition than in... |
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No. 102 | 03 Sept 2014 |
The Guidance Document for Using the OECD (Q)SAR Application Toolbox to Develop Chemical Categories According to the OECD Guidance on Grouping Chemicals
This document provides guidance on how to use the OECD (Q)SAR Application Toolbox to build chemical categories according to the OECD Guidance on Grouping of Chemicals. It is part of an overall effort to provide guidance on the use of the (Q)SAR... |
OECD Series on Testing and Assessment
This Series includes publications related to testing and assessment of chemicals; some of them support the development of OECD Test Guidelines (e.g. validation reports, guidance documents, detailed review papers).
Anglais
- ISSN : 20777876 (en ligne)
- https://doi.org/10.1787/20777876
61 - 80 of 144 results
Fish Toxicity Testing Framework
OCDE
03 Sept 2014
This document presents a review of fish toxicity testing for the regulatory purpose of chemical safety. The main focus is on fish toxicity, but fish bioaccumulation is also considered where relevant.
Performance Standards For Stably Transfected Transactivation In Vitro Assays To Detect Estrogen Receptor Antagonists - Second edition
OCDE
21 Aug 2015
This document includes the Performance Standards (PS) for stably transfected transactivation in vitroassays to detect estrogen receptor (ER) antagonists. These PS accompany the Performance-Based Test Guideline (PBTG) for Transfected Transactivation...
Performance Standards for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Agonists for TG 455
OCDE
01 Aug 2012
This document includes the Performance Standards (PS) for stably transfected transactivation in vitroassays to detect estrogen receptor (ER) antagonists. These PS accompany the Performance-Based Test Guideline (PBTG) for Transfected Transactivation...
The Adverse Outcome Pathway for Skin Sensitisation Initiated by Covalent Binding to Proteins
OCDE
03 Sept 2014
This document describes the state of knowledge of the adverse outcome pathway (AOP) for skin sensitisation initiated by covalent binding to proteins, assesses the weight-of-evidence supporting the AOP, identifies the key events, and identifies...
Guidance Document on the Collection of Eyes Tissues for Histological Evaluation and Collection of Data - Second Edition
OCDE
06 Jul 2018
This Guidance Document accompanies the OECD Test Guideline (TG) 437 on the bovine corneal opacity and permeability (BCOP) test method and TG 438 on the isolated chicken eye (ICE) test method. It provides users with guidelines for collecting...
Revised Guidance Document 150 on Standardised Test Guidelines for Evaluating Chemicals for Endocrine Disruption
OCDE
03 Sept 2018
This guidance document was originally published in 2012 and updated in 2018 to reflect new and updated OECD test guidelines, as well as reflect on scientific advances in the use of test methods and assessment of the endocrine activity of chemicals.
Guidance Document on the Androgenised Female Stickleback Screen
OCDE
08 Aug 2017
This guidance document describes an in vivo screening assay where sexually mature female sticklebacks are exposed to suspected anti-androgenic chemicals during a limited part of their life-cycle (21 days). The AFFS can detect both androgens and...
Detailed Review Paper on Environmental Endocrine Disruptor Screening: The Use of Estrogen and Androgen Receptor Binding and Transactivation Assays in Fish
OCDE
16 Sept 2010
The current Detailed Review Paper (DRP) has been developed under the Validation Management Groups for Ecotoxicity Testing (VMGeco) and Non-Animal testing (VMG NA). The DRP focuses on estrogen and androgen in vitro receptor and transcriptional...
Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systematic Toxicity Tests
OCDE
20 Jul 2010
This Guidance Document describes methods to determine the in vitro basal cytotoxicity of test substances using NRU assays and the use of the in vitro data to determine starting doses for in vivo acute oral systemic toxicity tests. The NRU assay is...
Short Guidance on the Treshold Approach for Acute Fish Toxicity
OCDE
31 May 2010
This document presents a short guidance on the Threshold Approach for Acute Fish Toxicity. In the interest of animal welfare and efficient use of resources, it is important to avoid the unnecessary use of animals whenever possible. In the field of...
The purpose of this Guidance Document (GD) is to provide pathologists, toxicologists, and associated scientists with recommended guidelines for performing the pathology tasks required by the specifications of TG 412 and 413, and for optimising the...
Guidance for the Derivation of an Acute Reference Dose
OCDE
07 Jun 2010
The objective of this document is to provide guidance on how to derive an Acute Reference Dose (ARfD). It outlines a stepwise approach on how to best use all available toxicological data, and what to do if more data are needed on the refinement of...
Guidance Document on the Diagnosis of Endocrine-related Histopathology in Fish Gonads
OCDE
31 May 2010
Exposure of fathead minnow (Pimephales promelas), Japanese medaka (Oryzias latipes) and zebrafish (Danio rerio) to endocrine disrupting chemicals may result in histopathological alterations of gonadal structure and microarchitecture. The diagnosis of...
Guidance Document on the Determination of the Toxicity of a Test Chemical to the Dung Beetle Aphodius Constans
OCDE
07 Jun 2010
This document presents the OECD Guidance Document on the Determination of the Toxicity of a Test Chemical to the Dung Beetle Aphodius Constans. This test method is designed to assess the effects of a test chemical, e.g. veterinary pharmaceuticals, to...
Detailed Review Paper (DRP) on Molluscs Life-cycle Toxicity Testing
OCDE
03 Sept 2014
This paper reviews what is known about the responses of molluscs to endocrine disrupting chemicals (EDCs), to consider whether it would be desirable and feasible to standardise mollusc-based partial- and full-lifecycle tests that are sensitive to...
This document constitutes an essential supplement to OECD Test Guideline 443 (EOGRTS) to describe the use of data gathered within the study to determine if a second generation should be produced. However, as a starting point, available mode of action...
Guidance Document 116 on the Conduct and Design of Chronic Toxicity and Carcinogenicity Studies, Supporting Test Guidelines 451, 452 and 453
OCDE
03 Sept 2014
This guidance provides additional information on the conduct of studies performed using Test Guidelines 451, 452 and Test Guideline 453.
Guidance Document for Histologic Evaluation of Endocrine and Reproductive Tests in Rodents
OCDE
28 Jul 2009
This Guidance Document has been prepared to provide the pathologist reading slides from endocrine and reproductive studies (eg the updated TG407 and longer studies) with sufficient information to be able to identify the often subtle histopathologic...
Detailed Review Paper on Transgenic Rodent Mutation Assays
OCDE
23 Jul 2009
Induced chromosomal and gene mutations cause genetic diseases, birth defects and other disease conditions and play a role in carcinogenesis. While it is widely accepted that in vivo mutation assays are more relevant to the human condition than in...
The Guidance Document for Using the OECD (Q)SAR Application Toolbox to Develop Chemical Categories According to the OECD Guidance on Grouping Chemicals
OCDE
03 Sept 2014
This document provides guidance on how to use the OECD (Q)SAR Application Toolbox to build chemical categories according to the OECD Guidance on Grouping of Chemicals. It is part of an overall effort to provide guidance on the use of the (Q)SAR...