This chapter explores public policy considerations to ensure that artificial intelligence (AI) systems are trustworthy and human-centred. It covers concerns related to ethics and fairness; the respect of human democratic values, including privacy; and the dangers of transferring existing biases from the analogue world into the digital world, including those related to gender and race. The need to progress towards more robust, safe, secure and transparent AI systems with clear accountability mechanisms for their outcomes is underlined. Policies that promote trustworthy AI systems include those that encourage investment in responsible AI research and development; enable a digital ecosystem where privacy is not compromised by a broader access to data; enable small and medium-sized enterprises to thrive; support competition, while safeguarding intellectual property; and facilitate transitions as jobs evolve and workers move from one job to the next.