This chapter presents an overview of policies to support start-ups in Colombia, focusing on changes that have taken place between 2012 and 2016. Like in other Latin American countries, the promotion of start-ups is an emerging and evolving topic in Colombia. In 2012, Colombia launched the iNNpulsa programme to promote entrepreneurship. Colombia’s pro-startup policy seeks to attract investment from financial institutions in start-ups, as well as to promote a business culture in the country. One prominent feature in the country is the growth of start-ups in cities like Bogotá and Medellín, which are looking to become hubs for start-ups in the country and in Latin America.