Mark | Date Date | Title Title | |||
---|---|---|---|---|---|
23 Nov 2004 |
Test No. 428: Skin Absorption: In Vitro Method
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ... |
||||
11 Sept 2006 |
Summary of Considerations in the Report from the OECD Expert Groups on Short Term and Long Term Toxicology
|
||||
15 Oct 2007 |
Test No. 426: Developmental Neurotoxicity Study
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ... |
||||
15 Oct 2007 |
Test No. 440: Uterotrophic Bioassay in Rodents
The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ... |
||||
16 Oct 2008 |
Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ... |
||||
08 Sept 2009 |
Test No. 436: Acute Inhalation Toxicity – Acute Toxic Class Method
The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ... |
||||
08 Sept 2009 |
Test No. 441: Hershberger Bioassay in Rats
The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ... |
||||
23 Jul 2010 |
Test No. 417: Toxicokinetics
This Test Guideline describes in vivo studies that provide information on mass balance, absorption, bioavailability, tissue distribution, metabolism, excretion, and basic toxicokinetic parameters [e.g. AUC], as well as supplemental approaches that ... |
||||
23 Jul 2010 |
Test No. 429: Skin Sensitisation
The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ... |
||||
23 Jul 2010 |
Test No. 442A: Skin Sensitization
The Local Lymph Node Assay: DA (LLNA: DA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The ... |
||||
02 Oct 2012 |
Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists
This Test Guideline describes an in vitro assay, which provides concentration-response data for substances with in vitro ER agonist and antagonist activity. The test system utilises the BG1Luc4E2 cell line derived from a human ovarian adenocarcinoma ... |
||||
28 Jul 2015 |
Test No. 404: Acute Dermal Irritation/Corrosion
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or... |
||||
28 Jul 2015 |
Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)
This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal... |
||||
28 Jul 2015 |
Test No. 435: In Vitro Membrane Barrier Test Method for Skin Corrosion
This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to... |
||||
29 Jul 2016 |
Test No. 421: Reproduction/Developmental Toxicity Screening Test
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. |
||||
29 Jul 2016 |
Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups... |
||||
29 Jul 2016 |
Test No. 473: In Vitro Mammalian Chromosomal Aberration Test
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells. |
||||
29 Jul 2016 |
Test No. 474: Mammalian Erythrocyte Micronucleus Test
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood... |
||||
29 Jul 2016 |
Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters). |
||||
29 Jul 2016 |
Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a... |
- Home
- Books
- OECD Guidelines for the Testing of Chemicals
- OECD Guidelines for the Testing of Chemicals, Section 4
OECD Guidelines for the Testing of Chemicals, Section 4
Health Effects
The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification, chemical registration and in chemical evaluation. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers health effects.
English Also available in: French
- ISSN: 20745788 (online)
- https://doi.org/10.1787/20745788
21 - 40 of 86 results
Test No. 428: Skin Absorption: In Vitro Method
OECD
23 Nov 2004
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
Summary of Considerations in the Report from the OECD Expert Groups on Short Term and Long Term Toxicology
OECD
11 Sept 2006
Test No. 426: Developmental Neurotoxicity Study
OECD
15 Oct 2007
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...
Test No. 440: Uterotrophic Bioassay in Rodents
OECD
15 Oct 2007
The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ...
Test No. 407: Repeated Dose 28-day Oral Toxicity Study in Rodents
OECD
16 Oct 2008
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The method is based on the repeated oral administration of the substance of interest during one limited period (one dose level ...
Test No. 436: Acute Inhalation Toxicity – Acute Toxic Class Method
OECD
08 Sept 2009
The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ...
Test No. 441: Hershberger Bioassay in Rats
OECD
08 Sept 2009
The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ...
Test No. 417: Toxicokinetics
OECD
23 Jul 2010
This Test Guideline describes in vivo studies that provide information on mass balance, absorption, bioavailability, tissue distribution, metabolism, excretion, and basic toxicokinetic parameters [e.g. AUC], as well as supplemental approaches that ...
Test No. 429: Skin Sensitisation
OECD
23 Jul 2010
The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ...
Test No. 442A: Skin Sensitization
OECD
23 Jul 2010
The Local Lymph Node Assay: DA (LLNA: DA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The ...
Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists
OECD
02 Oct 2012
This Test Guideline describes an in vitro assay, which provides concentration-response data for substances with in vitro ER agonist and antagonist activity. The test system utilises the BG1Luc4E2 cell line derived from a human ovarian adenocarcinoma ...
Test No. 404: Acute Dermal Irritation/Corrosion
OECD
28 Jul 2015
This method provides information on health hazard likely to arise from exposure to liquid or solid test substance by dermal application. It recommends sequential testing strategies, which include the performance of validated and accepted in vitro or...
Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)
OECD
28 Jul 2015
This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal...
This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to...
Test No. 421: Reproduction/Developmental Toxicity Screening Test
OECD
29 Jul 2016
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance.
Test No. 422: Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test
OECD
29 Jul 2016
This screening Test Guideline describes the effects of a test chemical on male and female reproductive performance. It has been updated with endocrine disruptor endpoints, in particular measure of anogenital distance and male nipple retention in pups...
Test No. 473: In Vitro Mammalian Chromosomal Aberration Test
OECD
29 Jul 2016
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Test No. 474: Mammalian Erythrocyte Micronucleus Test
OECD
29 Jul 2016
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood...
Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test
OECD
29 Jul 2016
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes
OECD
29 Jul 2016
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a...