Mark | Date Date | Title Title | |||
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29 Jul 2016 |
Test No. 478: Rodent Dominant Lethal Test
The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells. |
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29 Jul 2016 |
Test No. 483: Mammalian Spermatogonial Chromosomal Aberration Test
This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells. |
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29 Jul 2016 |
Test No. 489: In Vivo Mammalian Alkaline Comet Assay
The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells. |
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29 Jul 2016 |
Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay. |
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09 Oct 2017 |
Test No. 402: Acute Dermal Toxicity
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ... |
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27 Jun 2018 |
Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity... |
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27 Jun 2018 |
Test No. 412: Subacute Inhalation Toxicity: 28-Day Study
This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk ... |
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27 Jun 2018 |
Test No. 413: Subchronic Inhalation Toxicity: 90-day Study
This revised Test Guideline has been designed to fully characterize test article toxicity by the inhalation route for a subchronic duration (90 days), and to provide robust data for quantitative inhalation risk assessments. Groups of 10 male and 10 ... |
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27 Jun 2018 |
Test No. 414: Prenatal Developmental Toxicity Study
This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ... |
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27 Jun 2018 |
Test No. 451: Carcinogenicity Studies
The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of ... |
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27 Jun 2018 |
Test No. 452: Chronic Toxicity Studies
The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ... |
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27 Jun 2018 |
Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies
The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ... |
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27 Jun 2018 |
Test No. 443: Extended One-Generation Reproductive Toxicity Study
This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ... |
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27 Jun 2018 |
Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure
This method provides information on health hazard likely to arise from short-term exposure to a test chemical by inhalation. It is a principle of the method that only moderately toxic concentrations are used so that ‘evident toxicity’, rather than... |
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18 Jun 2019 |
Test No. 495: Ros (Reactive Oxygen Species) Assay for Photoreactivity
Phototoxicity is defined as a toxic response is elicited by topically or systemically administered photoreactive chemicals after the exposure of the body to environmental light. Several classes of photoreactive chemicals could cause phototoxic... |
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18 Jun 2019 |
Test No. 432: In Vitro 3T3 NRU Phototoxicity Test
This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ... |
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18 Jun 2019 |
Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using... |
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29 Jun 2020 |
Test No. 471: Bacterial Reverse Mutation Test
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ... |
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17 Jun 2021 |
Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2. |
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17 Jun 2021 |
Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays). |
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- OECD Guidelines for the Testing of Chemicals, Section 4
OECD Guidelines for the Testing of Chemicals, Section 4
Health Effects
The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification, chemical registration and in chemical evaluation. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers health effects.
English Also available in: French
- ISSN: 20745788 (online)
- https://doi.org/10.1787/20745788
41 - 60 of 86 results
Test No. 478: Rodent Dominant Lethal Test
OECD
29 Jul 2016
The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells.
Test No. 483: Mammalian Spermatogonial Chromosomal Aberration Test
OECD
29 Jul 2016
This test measures structural chromosomal aberrations (both chromosome- and chromatid-type) in dividing spermatogonial germ cells and is, therefore, expected to be predictive of induction of heritable mutations in these germ cells.
Test No. 489: In Vivo Mammalian Alkaline Comet Assay
OECD
29 Jul 2016
The in vivo alkaline single cell gel electrophoresis assay, also called alkaline Comet Assay is a method measuring DNA strand breaks in eukaryotic cells.
Test No. 490: In Vitro Mammalian Cell Gene Mutation Tests Using the Thymidine Kinase Gene
OECD
29 Jul 2016
This TG includes two distinct in vitro mammalian gene mutation assays requiring two specific tk heterozygous cells lines: L5178Y tk+/-3.7.2C cells for the mouse lymphoma assay (MLA) and TK6 tk+/- cells for the TK6 assay.
Test No. 402: Acute Dermal Toxicity
OECD
09 Oct 2017
This method provides information on health hazard likely to arise from a short-term exposure to solid or liquid test substance by the dermal route. This Test Guideline is intended primarily for use with rodents (rat, rabbit or guinea pig may be ...
Test No. 408: Repeated Dose 90-Day Oral Toxicity Study in Rodents
OECD
27 Jun 2018
This method provides information on health hazard likely to arise from exposure to test substance via oral administration. The determination of sub-chronic oral toxicity using repeated doses may be carried out after initial information on toxicity...
Test No. 412: Subacute Inhalation Toxicity: 28-Day Study
OECD
27 Jun 2018
This revised Test Guideline 412 (TG 412) has been designed to fully characterize test article toxicity by the inhalation route following repeated exposure for a limited period of time (28 days), and to provide data for quantitative inhalation risk ...
Test No. 413: Subchronic Inhalation Toxicity: 90-day Study
OECD
27 Jun 2018
This revised Test Guideline has been designed to fully characterize test article toxicity by the inhalation route for a subchronic duration (90 days), and to provide robust data for quantitative inhalation risk assessments. Groups of 10 male and 10 ...
Test No. 414: Prenatal Developmental Toxicity Study
OECD
27 Jun 2018
This Test Guideline for developmental toxicity testing is designed to provide general information concerning the effects of prenatal exposure on the pregnant test animal and on the developing organism. The test substance is normally administered to ...
Test No. 451: Carcinogenicity Studies
OECD
27 Jun 2018
The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of ...
Test No. 452: Chronic Toxicity Studies
OECD
27 Jun 2018
The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...
Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies
OECD
27 Jun 2018
The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ...
Test No. 443: Extended One-Generation Reproductive Toxicity Study
OECD
27 Jun 2018
This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
This method provides information on health hazard likely to arise from short-term exposure to a test chemical by inhalation. It is a principle of the method that only moderately toxic concentrations are used so that ‘evident toxicity’, rather than...
Phototoxicity is defined as a toxic response is elicited by topically or systemically administered photoreactive chemicals after the exposure of the body to environmental light. Several classes of photoreactive chemicals could cause phototoxic...
Test No. 432: In Vitro 3T3 NRU Phototoxicity Test
OECD
18 Jun 2019
This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ...
Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method
OECD
18 Jun 2019
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using...
Test No. 471: Bacterial Reverse Mutation Test
OECD
29 Jun 2020
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).