Mark | Date Date | Title Title | |||
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29 Jul 2016 |
Test No. 478: Rodent Dominant Lethal Test
The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells. |
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04 Apr 1984 |
Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster
Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ... |
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29 Jul 2016 |
Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a... |
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29 Jul 2016 |
Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters). |
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29 Jul 2016 |
Test No. 474: Mammalian Erythrocyte Micronucleus Test
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood... |
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29 Jul 2016 |
Test No. 473: In Vitro Mammalian Chromosomal Aberration Test
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells. |
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29 Jun 2020 |
Test No. 471: Bacterial Reverse Mutation Test
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ... |
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30 Jun 2022 |
Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene... |
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25 Jun 2024 |
Test No. 467: Defined Approaches for Serious Eye Damage and Eye Irritation
This Test Guideline proposes defined approaches (DA) combining data generated in vitro methods, with information sources such as physicochemical properties. |
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04 Jul 2023 |
Test No. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants
This Test Guideline describes an in vitro assay that may be used for identifying water soluble ocular corrosives and severe irritants as defined by the UN Globally Harmonized System of Classification and Labelling, Category 1. The assay is performed ... |
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04 Jul 2023 |
Test No. 458: Stably Transfected Human Androgen Receptor Transcriptional Activation Assay for Detection of Androgenic Agonist and Antagonist Activity of Chemicals
This Test Guideline describes in vitro assays, which use Androgen Receptor TransActivation (ARTA) to detect Androgen Receptor Agonists and Antagonists. The ARTA assay methods are mechanistically and functionally similar test methods that provide... |
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02 Oct 2012 |
Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists
This Test Guideline describes an in vitro assay, which provides concentration-response data for substances with in vitro ER agonist and antagonist activity. The test system utilises the BG1Luc4E2 cell line derived from a human ovarian adenocarcinoma ... |
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04 Jul 2023 |
Test No. 456: H295R Steroidogenesis Assay
This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that ... |
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17 Jun 2021 |
Test No. 455: Performance-Based Test Guideline for Stably Transfected Transactivation In Vitro Assays to Detect Estrogen Receptor Agonists and Antagonists
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays). |
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27 Jun 2018 |
Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies
The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ... |
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27 Jun 2018 |
Test No. 452: Chronic Toxicity Studies
The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ... |
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27 Jun 2018 |
Test No. 451: Carcinogenicity Studies
The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of ... |
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04 Jul 2023 |
Test No. 444A: In Vitro Immunotoxicity
This Test Guideline (TG) describes the IL-2 Luc Assay test method to evaluate the potential immunotoxic effects of chemicals on T lymphoblastic cell line. This cell line allows quantitative measurement of luciferase gene induction by detecting... |
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27 Jun 2018 |
Test No. 443: Extended One-Generation Reproductive Toxicity Study
This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ... |
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25 Jun 2024 |
Test No. 442E: In Vitro Skin Sensitisation
The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical,... |
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- OECD Guidelines for the Testing of Chemicals
- OECD Guidelines for the Testing of Chemicals, Section 4
OECD Guidelines for the Testing of Chemicals, Section 4
Health Effects
The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification, chemical registration and in chemical evaluation. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers health effects.
English Also available in: French
- ISSN: 20745788 (online)
- https://doi.org/10.1787/20745788
21 - 40 of 86 results
Test No. 478: Rodent Dominant Lethal Test
OECD
29 Jul 2016
The purpose of the Dominant lethal (DL) test is to investigate whether chemical agents produce mutations resulting from chromosomal aberrations in germ cells.
Test No. 477: Genetic Toxicology: Sex-Linked Recessive Lethal Test in Drosophila melanogaster
OECD
04 Apr 1984
Mutations in the X-chromosome of Drosophila melanogaster are phenotypically expressed in males carrying the mutant gene. When the mutation is lethal in the hemizygous condition, its presence is inferred from the absence of one class of male ...
Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes
OECD
29 Jul 2016
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a...
Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test
OECD
29 Jul 2016
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters).
Test No. 474: Mammalian Erythrocyte Micronucleus Test
OECD
29 Jul 2016
The mammalian in vivo micronucleus test is used for the detection of damage induced by the test substance to the chromosomes or the mitotic apparatus of erythroblasts, by analysis of erythrocytes as sampled in bone marrow and/or peripheral blood...
Test No. 473: In Vitro Mammalian Chromosomal Aberration Test
OECD
29 Jul 2016
This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Test No. 471: Bacterial Reverse Mutation Test
OECD
29 Jun 2020
The bacterial reverse mutation test uses amino-acid requiring at least five strains of Salmonella typhimurium and Escherichia coli to detect point mutations by base substitutions or frameshifts. The principle of this bacterial reverse mutation test ...
Test No. 470: Mammalian Erythrocyte Pig-a Gene Mutation Assay
OECD
30 Jun 2022
This Test Guideline describes an in vivo erythrocyte Pig-a gene mutation assay (hereafter called the Pig-a assay) which uses an endogenous mammalian gene, the phosphatidylinositol glycan class A gene (Pig-a), as a reporter of somatic-cell gene...
This Test Guideline proposes defined approaches (DA) combining data generated in vitro methods, with information sources such as physicochemical properties.
Test No. 460: Fluorescein Leakage Test Method for Identifying Ocular Corrosives and Severe Irritants
OECD
04 Jul 2023
This Test Guideline describes an in vitro assay that may be used for identifying water soluble ocular corrosives and severe irritants as defined by the UN Globally Harmonized System of Classification and Labelling, Category 1. The assay is performed ...
This Test Guideline describes in vitro assays, which use Androgen Receptor TransActivation (ARTA) to detect Androgen Receptor Agonists and Antagonists. The ARTA assay methods are mechanistically and functionally similar test methods that provide...
Test No. 457: BG1Luc Estrogen Receptor Transactivation Test Method for Identifying Estrogen Receptor Agonists and Antagonists
OECD
02 Oct 2012
This Test Guideline describes an in vitro assay, which provides concentration-response data for substances with in vitro ER agonist and antagonist activity. The test system utilises the BG1Luc4E2 cell line derived from a human ovarian adenocarcinoma ...
Test No. 456: H295R Steroidogenesis Assay
OECD
04 Jul 2023
This Test Guideline describes an in vitro screen for chemical effects on steroidogenesis, specifically the production of 17ß-estradiol (E2) and testosterone (T). The human H295R adreno-carcinoma cell line, used for the assay, expresses genes that ...
This Performance-Based Test Guideline (PBTG) describes in vitro assays, which provide the methodology of Stably Transfected Transactivation to detect Estrogen Receptor Agonists and Antagonists (ER TA assays).
Test No. 453: Combined Chronic Toxicity/Carcinogenicity Studies
OECD
27 Jun 2018
The objective of a combined chronic toxicity/carcinogenicity study is to identify carcinogenic and the majority of chronic effects, and to determine dose-response relationships following prolonged and repeated exposure. The rat is typically used for ...
Test No. 452: Chronic Toxicity Studies
OECD
27 Jun 2018
The objective of these chronic toxicity studies is to characterize the profile of a substance in a mammalian species (primarily rodents) following prolonged and repeated exposure. The Test Guideline focuses on rodents and oral administration. Both ...
Test No. 451: Carcinogenicity Studies
OECD
27 Jun 2018
The objective of a long-term carcinogenicity study is to observe test animals for a major portion of their life span for the development of neoplastic lesions during or after exposure to various doses of a test substance by an appropriate route of ...
Test No. 444A: In Vitro Immunotoxicity
OECD
04 Jul 2023
This Test Guideline (TG) describes the IL-2 Luc Assay test method to evaluate the potential immunotoxic effects of chemicals on T lymphoblastic cell line. This cell line allows quantitative measurement of luciferase gene induction by detecting...
Test No. 443: Extended One-Generation Reproductive Toxicity Study
OECD
27 Jun 2018
This Test Guideline is designed to provide an evaluation of reproductive and developmental effects that may occur as a result of pre- and postnatal chemical exposure as well as an evaluation of systemic toxicity in pregnant and lactating females and ...
Test No. 442E: In Vitro Skin Sensitisation
OECD
25 Jun 2024
The present Key Event based Test Guideline (TG) addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical,...