Mark | Date Date | Title Title | |||
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25 Jun 2024 |
Test No. 442D: In Vitro Skin Sensitisation
The present Key Event based Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with a tested chemical, as... |
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25 Jun 2024 |
Test No. 442C: In Chemico Skin Sensitisation
The present Key Event based Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as... |
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25 Jun 2024 |
Test No. 442B: Skin Sensitization
The Local Lymph Node Assay: BrdU-ELISA (LLNA:BrdU-ELISA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular ... |
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23 Jul 2010 |
Test No. 442A: Skin Sensitization
The Local Lymph Node Assay: DA (LLNA: DA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The ... |
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08 Sept 2009 |
Test No. 441: Hershberger Bioassay in Rats
The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ... |
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15 Oct 2007 |
Test No. 440: Uterotrophic Bioassay in Rodents
The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ... |
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17 Jun 2021 |
Test No. 439: In Vitro Skin Irritation: Reconstructed Human Epidermis Test Method
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2. |
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04 Jul 2023 |
Test No. 438: Isolated Chicken Eye Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
The Isolated Chicken Eye Test (ICE) Method is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing “serious eye damage” (category 1 of the Globally Harmonised System for the Classification and ... |
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04 Jul 2023 |
Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying i) Chemicals Inducing Serious Eye Damage and ii) Chemicals Not Requiring Classification for Eye Irritation or Serious Eye Damage
The Bovine Corneal Opacity and Permeability test method (BCOP) is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing “serious eye damage” (category 1 of the Globally Harmonised System for the... |
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08 Sept 2009 |
Test No. 436: Acute Inhalation Toxicity – Acute Toxic Class Method
The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ... |
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28 Jul 2015 |
Test No. 435: In Vitro Membrane Barrier Test Method for Skin Corrosion
This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to... |
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27 Jun 2018 |
Test No. 433: Acute Inhalation Toxicity: Fixed Concentration Procedure
This method provides information on health hazard likely to arise from short-term exposure to a test chemical by inhalation. It is a principle of the method that only moderately toxic concentrations are used so that ‘evident toxicity’, rather than... |
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18 Jun 2019 |
Test No. 432: In Vitro 3T3 NRU Phototoxicity Test
This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ... |
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18 Jun 2019 |
Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using... |
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28 Jul 2015 |
Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)
This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal... |
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23 Jul 2010 |
Test No. 429: Skin Sensitisation
The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ... |
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23 Nov 2004 |
Test No. 428: Skin Absorption: In Vitro Method
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ... |
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23 Nov 2004 |
Test No. 427: Skin Absorption: In Vivo Method
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ... |
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15 Oct 2007 |
Test No. 426: Developmental Neurotoxicity Study
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ... |
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30 Jun 2022 |
Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure
The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals. It is easiest to ... |
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- OECD Guidelines for the Testing of Chemicals
- OECD Guidelines for the Testing of Chemicals, Section 4
OECD Guidelines for the Testing of Chemicals, Section 4
Health Effects
The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals. They are a set of tools for professionals, used primarily in regulatory safety testing and subsequent chemical and chemical product notification, chemical registration and in chemical evaluation. They can also be used for the selection and ranking of candidate chemicals during the development of new chemicals and products and in toxicology research. This group of tests covers health effects.
English Also available in: French
- ISSN: 20745788 (online)
- https://doi.org/10.1787/20745788
41 - 60 of 86 results
Test No. 442D: In Vitro Skin Sensitisation
OECD
25 Jun 2024
The present Key Event based Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with a tested chemical, as...
Test No. 442C: In Chemico Skin Sensitisation
OECD
25 Jun 2024
The present Key Event based Test Guideline addresses the human health hazard endpoint skin sensitisation, following exposure to a test chemical. Skin sensitisation refers to an allergic response following skin contact with the tested chemical, as...
Test No. 442B: Skin Sensitization
OECD
25 Jun 2024
The Local Lymph Node Assay: BrdU-ELISA (LLNA:BrdU-ELISA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular ...
Test No. 442A: Skin Sensitization
OECD
23 Jul 2010
The Local Lymph Node Assay: DA (LLNA: DA) is a non-radioactive modification to the LLNA method for identifying potential skin sensitizing test substances and measuring the proliferation of lymphocytes they induce in the auricular lymph nodes. The ...
Test No. 441: Hershberger Bioassay in Rats
OECD
08 Sept 2009
The Hershberger Bioassay is an in vivo short–term screening test. It evaluates the ability of a chemical to elicit biological activities consistent with androgen agonists, antagonists or 5 á-reductase inhibitors. The current bioassay is based on the ...
Test No. 440: Uterotrophic Bioassay in Rodents
OECD
15 Oct 2007
The Uterotrophic Bioassay is an in vivo short-term screening test. It is based on the increase in uterine weight or uterotrophic response. The Uterotrophic Bioassay relies for its sensitivity on an animal test system in which the ...
This Test Guideline describes an in vitro procedure that may be used for the hazard identification of irritant chemicals (substances and mixtures) in accordance with the UN Globally Harmonized System of Classification and Labelling (GHS) Category 2.
The Isolated Chicken Eye Test (ICE) Method is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing “serious eye damage” (category 1 of the Globally Harmonised System for the Classification and ...
The Bovine Corneal Opacity and Permeability test method (BCOP) is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing “serious eye damage” (category 1 of the Globally Harmonised System for the...
Test No. 436: Acute Inhalation Toxicity – Acute Toxic Class Method
OECD
08 Sept 2009
The method described by this Test Guideline provides information that allows hazard assessment for short-term exposure to a test article by inhalation, and allows the substance to be classified according to the Globally Harmonized System of ...
This updated Test Guideline 435 provides an in vitro membrane barrier test method that can be used to identify corrosive chemicals. The test method utilizes an artificial membrane designed to respond to corrosive chemicals in a manner similar to...
This method provides information on health hazard likely to arise from short-term exposure to a test chemical by inhalation. It is a principle of the method that only moderately toxic concentrations are used so that ‘evident toxicity’, rather than...
Test No. 432: In Vitro 3T3 NRU Phototoxicity Test
OECD
18 Jun 2019
This Test Guideline describes a method to evaluate photo-cytotoxicity by the relative reduction in viability of cells exposed to the chemical in the presence versus absence of light. Balb/c 3T3 cells are maintained in culture for 24 h for formation ...
Test No. 431: In vitro skin corrosion: reconstructed human epidermis (RHE) test method
OECD
18 Jun 2019
The test described in this Test Guideline allows the identification of corrosive chemical substances and mixtures and it enables the identification of non-corrosive substances and mixtures when supported by a weight of evidence determination using...
Test No. 430: In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test Method (TER)
OECD
28 Jul 2015
This Test Guideline addresses the human health endpoint skin corrosion. It is based on the rat skin transcutaneous electrical resistance (TER) test method, which utilizes skin discs to identify corrosives by their ability to produce a loss of normal...
Test No. 429: Skin Sensitisation
OECD
23 Jul 2010
The basic principle underlying the Local Lymph Node Assay (LLNA) in mouse is that sensitizers induce a primary proliferation of lymphocytes in the auricular lymph nodes draining the site of chemical application. This proliferation is proportional to ...
Test No. 428: Skin Absorption: In Vitro Method
OECD
23 Nov 2004
This Test method has been designed to provide information on absorption of a test substance, (ideally radiolabelled), applied to the surface of a skin sample separating the two chambers (a donor chamber and a receptor chamber) of a diffusion cell ...
Test No. 427: Skin Absorption: In Vivo Method
OECD
23 Nov 2004
The in vivo percutaneous absorption study set out in this Test Guideline provides the linkage necessary to extrapolate from oral studies when making safety assessments following dermal exposure. The in vivo method, described in this guideline ...
Test No. 426: Developmental Neurotoxicity Study
OECD
15 Oct 2007
A developmental neurotoxicity study will provide information on the effects of repeated exposure to a substance during in utero and early postnatal development. The test substance is administered daily, generally orally, to mated females (rats are ...
Test No. 425: Acute Oral Toxicity: Up-and-Down Procedure
OECD
30 Jun 2022
The method permits estimation of an LD50 with a confidence interval and the results allow a substance to be classified for acute toxicity according to the Globally Harmonised System of classification and labelling of chemicals. It is easiest to ...